巯-烯点击反应在毛细管整体柱制备中的应用  

Application of Thiol-Ene “Click”Reactions in the Preparation of Monolithic Columns

作　　者：熊喜悦[1] 彭泽强 舒彦[1] 何海琴[1] 陈应庄[1] 陈波[1] 

机构地区：[1]湖南师范大学化学生物学及中药分析省部共建教育部重点实验室,长沙410081 [2]湖南新麓南环保工程有限公司,长沙410081

出　　处：《化学进展》2014年第1期152-157,共6页Progress in Chemistry

摘　　要：毛细管整体柱由于具备高效的传质性能、分离性能以及灵活的可设计性,受到科研工作者的广泛关注。整体柱制备过程中,功能基团的引入是关键点之一。近年来研究者们将一种简单高效、定向性强的反应-"巯-烯点击反应"引入整体柱的制备中,由于含巯基、含烯键的配体和单体具有非常广泛的可选择性,因而使整体柱材料更加多样化。本文从整体柱的特征、分类及制备方法出发,阐述了传统整体柱制备方法的局限性以及引入巯-烯点击反应的优势。并且分别从两个方面重点综述了"巯-烯点击反应"在整体柱制备中的应用:即利用巯-烯点击反应对表面含烯键或者巯基的整体柱进行表面修饰以及基于巯-烯点击反应"一锅法"制备的杂化整体柱。最后展望了巯-烯点击反应在整体柱制备领域的发展前景。Due to the easier preparation,better permeability and higher column efficiency over traditional packed columns,monolithic columns have gained increasing interest as separation media in all chromatographic methods. In recent years,w ith the rapid development of nanoscale chromatographic separation systems,the use of capillary monolithic columns have emerged as a promising choice. According to the chemical composition of monoliths,monolithic columns can be mainly classified into organic polymer-based,silica-based and organicsilica hybrid monolithic columns. Each of monoliths is tended to be prepared w ith versatile functionality. How ever,silica-based monoliths aw ays suffer from limited silylating reagents and complex processes of modifications,and conventional approaches of preparing polymer-based monoliths and organic-silica hybrid monoliths also prevent their development due to the special requirements of functional monomers（ possess vinyl or acrylate groups）. Recently,thiol-ene ＂click＂reaction has already received extensive attention in the field of monolith preparation ow ing to its exceptional versatility and propensity for the quantitative conversions under mild conditions,extending the choice of categories of functional monomers to some extent. Herein,the fabrication approaches are comprehensively summarized w ith tw o routes：（ 1） surface modification of monoliths via thiol-ene ＂click＂reaction,（ 2） ＂one-pot＂synthesis of monolithic columns via thiol-ene＂click＂reaction.

关 键 词：整体柱 功能单体 巯-烯点击反应 一锅法 表面修饰 

分 类 号：O657.7[理学—分析化学] O633[理学—化学]