血管紧张素-(1-7)在血管紧张素Ⅱ诱导心肌细胞肥大中的作用  

The role of angiotensin-(1-7)in myocardial cell hypertrophy induced by angiotensin

作　　者：曾武涛[1] 马虹[1] 鲁伟[2] 潘敬运[2] 王礼春[1] 唐安丽[1] 

机构地区：[1]中山医科大学附属第一医院心血管医学部心内科,广州 510080 [2]中山医科大学生理学教研室

出　　处：《中华心血管病杂志》2000年第6期460-463,共4页Chinese Journal of Cardiology

摘　　要：目的　探讨血管紧张素 (1 7) [Ang (1 7) ]在血管紧张素Ⅱ (AngⅡ )诱导心肌细胞肥大反应中的作用。方法　在AngⅡ诱导培养的SD乳鼠心肌细胞中 ,应用Ang (1 7) ,通过测定心肌细胞蛋白质合成速率 ,蛋白质含量和细胞表面积等指标 ,观察心肌细胞肥大情况。结果　Ang (1 7)呈剂量依赖性抑制AngⅡ诱导培养的心肌细胞的蛋白质合成速率 ,Ang (1 7)还能减少AngⅡ诱导培养的心肌细胞的细胞蛋白质含量和表面积。其作用受体不是血管紧张素Ⅱ受体 1(AT1 )或血管紧张素Ⅱ受体 2 (AT2 ) ,而是通过一种特殊受体介导。结论　Ang (1 7)能抑制AngⅡ诱导的心肌细胞肥大 ,其作用是通过一种特殊受体介导。Objective To investigate the role of angiotensin (1 7) [Ang (1 7)] in myocardial cell hypertrophy induced by angiotensin Ⅱ (Ang Ⅱ). Methods Ang (1 7) was used in neonatal SD rats myocardial cells cultured in vitro induced by Ang Ⅱ. The protein synthetic rate, protein amounts and surface area of myocardial cells were employed to detect myocardial cell hypertrophy. Results Ang (1 7) inhibited synthetic rate of myocardial cells induced by Ang Ⅱ in a dose dependent manner, Ang (1 7) also reduced protein amounts and surface area of myocardial cells induced by Ang Ⅱ . The receptor of Ang (1 7) action was not AT 2 or AT 1 receptor, but a special receptor. Conclusion Ang (1 7) can inhibit myocardial cells hypertrophy induced by Ang Ⅱ through a special receptor.

关 键 词：心肌细胞肥大 血管紧张素-(1-7) 血管紧张素Ⅱ 

分 类 号：R341[医药卫生—基础医学]