匹多莫德联合抗真菌药物治疗复发性念珠菌性阴道炎的疗效观察  

作　　者：宗国霞 

机构地区：[1]佛山市第四人民医院,广东528000

出　　处：《当代医学》2014年第1期99-100,共2页Contemporary Medicine

摘　　要：目的探讨匹多莫德联合抗真菌药物治疗复发性念珠菌性阴道炎(recurrent vulvovaginal candidiasis,RVVC)的疗效。方法将134例RVVC患者分为三组,分别给予单纯硝呋太尔、斯匹仁诺联合硝呋太尔、匹多莫德联合硝呋太尔与斯匹仁诺治疗,疗程结束后随访并行病原学检查,疗效以治愈率和有效率表示。结果单纯硝呋太尔组治愈率和有效率分别为20.45%和70.45%,硝呋太尔联合斯匹仁诺组治愈率和有效率分别为38.09%和71.48%,匹多莫德联合硝呋太尔、斯匹仁诺组治愈率和有效率分别为47.92%和87.50%。匹多莫德联合抗真菌药疗效较单纯使用硝呋太尔有显著提升(P<0.05)。结论匹多莫德联合抗真菌药物治疗RVVC疗效确切,推广应用时应权衡联合用药的毒副作用和经济性。Objective To discuss effect of pidotimod combined with antifungal drugs on recurrent vulvovaginal candidasis（RVVC）. Methods 134 RVVC patients were divided into three groups, and then been treated with single nifuratel nysfungin vaginal soft capsules, Itraconazole capsules combined with nifuratel, pidotimod dispersible tablets combined with nifuratel and itraconazole respectively. All patients had been followed up after the end of treatment, meanwhile aetiological examination had been done. Cure rate and efficacy rate expressed as index of treatment effect were calculated. Results Among single nifuratel group, itraconazole combined nifuratel group and pidotimod combined antifungal drugs group, the cure rate and efficacy rate were 20.45%and 70.45%, 38.09%and 71.48%, 47.92%and 87.50%respectively. Effect of pidotimod combined with antifungal drugs is significant stronger than nifuratel single using （P〈0.05）. Conclusion Therapeutic regimen of pidotimod combined with antifungal drugs is effective in the treatment of RVVC, but side-effect and economy of drugs combination should be considered in popularizing.

关 键 词：念珠菌病 外阴阴道 抗真菌药 匹多莫德 

分 类 号：R711.3[医药卫生—妇产科学]