帕瑞昔布钠用于颈椎前路手术后镇痛的临床观察  

Efficacy of parecoxib analgesia after anterior cervical surgery

作　　者：刘斌 王济纬[1] 张立岩[1] 樊理华[1] 

机构地区：[1]丽水市人民医院(温州医科大学附属第六医院)骨科,浙江丽水323000

出　　处：《临床骨科杂志》2013年第6期616-618,共3页Journal of Clinical Orthopaedics

基　　金：丽水市科技局科技项目(编号:2012ZC038)

摘　　要：目的探讨帕瑞昔布钠在颈椎前路手术后镇痛的效果及安全性。方法选择全身麻醉下骨科颈椎前路手术后患者60例,随机分为3组(每组20例):A1组(帕瑞昔布钠40 mg静脉推注,q12 h×6次+自控静脉镇痛泵组),A2组(帕瑞昔布钠40 mg静脉推注,q 12 h×6次),B组(单用自控静脉镇痛泵)。记录术后1、6、12、24、48、72 h的VAS疼痛评分和吗啡用量,观察不良反应率。结果 A1、A2组术后72 h内VAS评分和不良反应发生率均优于B组;A1组吗啡使用量少于B组(P<0.05);A1与A2组术后72 h内VAS评分比较差异无统计学意义(P>0.05),但A2组的不良反应发生率低于A1组(P<0.05)。结论帕瑞昔布钠具有高效和安全的镇痛特性,对于颈椎前路手术后患者镇痛效果良好。Objective To investigate the parecoxib efficacy and safety in the anterior cervical surgery postoperative analgesia. Methods 60 cases of anterior cervical spine surgery under general anesthesia were randomly divided into three groups （n = 20） ： Group A1 （parecoxib sodium 40rag bolus, q12h × 6 times ＋ controlled intravenous analgesia pump）, Group A2 （pareeoxib sodium 40mg bolus, q 12h x 6 times）, Group B （alone controlled intravenous analgesia pump）. 1,6,12,24,48,72 h after surgery, the VAS pain scores and morphine dosage, adverse reaction rates were observed. Results A1, A2 within 72h postoperative VAS scores and incidence rate of adverse reactions were better than in group B; Group A1 used less morphine in group B （P 〈0.05） ; A1 and A2 within 72h postoperative VAS scores showed no statistical significance （ P 〉 0.05 ）, but the Group A2 the incidence of adverse reactions than Group A1 （ P 〈 0. 05 ）. Conclusions Parecoxib has the efficient and safe analgesic properties. For patients with anterior cervical surgery, the postoperative analgesic effect is good.

关 键 词：帕瑞昔布钠 环氧化酶-2抑制剂 脊柱手术 术后镇痛 

分 类 号：R687.3[医药卫生—骨科学] R614[医药卫生—外科学]