小口径人工血管及制备方法的研究进展  

Progresses in Artificial Small-Diameter Blood Vessel Grafts and their Preparation Methods

作　　者：王甩艳 赖琛[2] 奚廷斐[1,2] 

机构地区：[1]温州医科大学检验医学院生命科学学院,温州325035 [2]北京大学深圳研究院生物医学工程研究中心,深圳518057

出　　处：《中国生物医学工程学报》2013年第6期723-730,共8页Chinese Journal of Biomedical Engineering

基　　金：国家重点基础研究发展计划(973计划)(2012CB933600)

摘　　要：血管移植是治疗心血管疾病的主要手段之一。小口径人工血管的研发也成为近十年来的研究热点。本文从制备小口径人工血管的材料和方法方面,首先简述了人工合成材料和天然生物材料,然后介绍了近些年来浸渍-沥滤法、混凝法、去细胞组织复合法、静电纺丝法、旋转曝光法、组织工程血管支架法及3 D快速成型技术应用等的研究进展。阐述了作为小口径人工血管的各种材料和制备方法的特点,为理想的小口径人造血管进一步的发展提供了一定的参考。最后对小口径人工血管发展前景做了展望。Vascular transplantation is one of the main methods in the treatment of cardiovascular diseases. The development of small caliber artificial blood vessel also becomes the focus in the nearly 10 years. This paper introduces the research progress from the aspects of materials and methods of the preparation of small diameter artificial blood vessels in recent years. First we describe the synthetic materials and natural biological materials, then introduce the research progress dip - leaching method, coagulation method, deeellularization organization composition, electrostatic spinning method, rotating exposure method, tissue engineering blood vessel scaffold method and 3D rapid prototyping technology. It presents the characteristics of different materials and preparation methods for uses in small caliber artificial blood vessels and provides certain reference for further developments of ideal artificial blood vessels as well as its prospects.

关 键 词：小口径人工血管 血管材料 制备方法 

分 类 号：R318.08[医药卫生—生物医学工程]