超声可控释药体系研究进展  

Recent Advances in the Ultrasound-Mediated Drug Delivery Systems

作　　者：包敏[1] 周宇峰[2] 周祺惠[1] 董文[1] 张彦中[1] 

机构地区：[1]东华大学化学化工与生物工程学院,上海201620 [2]南洋理工大学机械与宇航学院超声科学与应用研究实验室,新加坡639798

出　　处：《中国生物医学工程学报》2013年第6期731-740,共10页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(51073032);中央高校基本科研业务费专项资金(11D10540);东华大学硕士研究生创新基金(105-06-0019033)

摘　　要：超声可控释药体系是一种新兴的靶向给药及基因转运方法。以超声敏感材料作为药物或基因转送的载体,当超声辐照于靶组织或靶器官时,靶体内载体可定向释放出包裹或附着的基因或药物,实现对负载药物的定时定量定点释放和提高药物输送效率或基因转染率的目的。文中对超声可控释药体系的作用机制、超声敏感载体材料及生物医学应用等方面进行综述,最后对该领域目前存在的问题和今后的发展方向提出了一些看法。Ultrasound-controlled drug delivery systems have emerged as a new method in the field of targeted drug delivery and gene transfer. Under ultrasound radiation, drug-loaded or gene transfer depots made of ultrasound-sensitive materials, are able to release genes or drugs on-demand, thus improving temporospatial control in drug delivery and gene transfection efficiency. This article reviews the recent advances in ultrasound- controlled drug delivery systems including the mechanism of ultrasound-mediated drug delivery, ultrasound- sensitive drug- and/or gene-loaded carriers, and biomedical applications. Finally, the existing problems and future trends in this niche area are discussed as well.

关 键 词：超声敏感材料 药物递送系统 控释 组织工程 

分 类 号：R318[医药卫生—生物医学工程]