高血压患者血浆同型半胱氨酸水平与颈动脉硬化及性别的关系  

Relationship between serum homocysteine level and carotid atherosclerosis and sex in hypertension

作　　者：张勤勤[1] 许寅宏[1] 邱少东[1] 

机构地区：[1]广州医科大学第二附属医院,广东广州510260

出　　处：《医学影像学杂志》2013年第12期1891-1893,共3页Journal of Medical Imaging

摘　　要：目的探讨高血压患者颈动脉硬化及性别与血浆同型半胱氨酸(Hcy)的关系。方法选择高血压患者216例,根据颈动脉超声分为正常组、颈动脉硬化组和斑块组,斑块组又分为稳定斑块组和不稳定斑块组,采用彩色多普勒超声仪检测颈动脉内膜中层厚度(IMT)及斑块,同时测定血Hcy。结果正常组、颈动脉硬化组和斑块组血Hcy蛋氨酸和半胱氨酸代谢中间产物差异有统计学意义;不稳定斑块组和稳定斑块血Hcy差异有统计学意义(P<0.01);男性高血压患者血浆Hcy水平高于女性患者(P<0.01)。结论高血压患者血Hcy与动脉硬化程度、斑块稳定性及性别密切相关。Objective To discuss the relationship between homocysteine （Hcy） and carotid atherosclerosis and sex in the hypertensive patients. Methods 216 patients who had hypertension were selected, according to the results of carotid ar tery ultrasonography, all patients were divided into normal group, carotid atheroselerosis group, and carotid plaque group, and carotid plaque group were further divided into stable group and unstable group. Intima-medial thickness （IMT） and the plaque of carotid were examined with color Doppler ultrasound, blood serum Hcy level were measured. Results There were significant differenles of blood serum Hcy level in normal group, carotid atherosclerosis group, carotid plaque group, stable group and unstable group （ P d〈. 01）. There was significant deviation in Hcy [eve （ P 〈O. 01） between male and female hypertension patients. Conclusion There was close correlation between Hcy and the degree of carotid atheroselero sis and sex in the hypertensive patients.

关 键 词：高血压 同型半胱氨酸 颈动脉硬化 超声检查 

分 类 号：R543.2[医药卫生—心血管疾病] R445.1[医药卫生—内科学]