仙人掌总黄酮对小鼠抗急性炎症作用的研究  

Study on the Anti-acute Inflammation Effect of Opuntia Total Flavonoids in Mice

作　　者：戴小华[1] 李春红[2] 阿依姑丽.艾合买提 徐琳[1] 骆秀珍 

机构地区：[1]新疆农业大学食品科学与药学学院,乌鲁木齐830052 [2]新疆农业大学科学技术学院,乌鲁木齐830052

出　　处：《中国农学通报》2013年第36期400-403,共4页Chinese Agricultural Science Bulletin

基　　金：新疆维吾尔自治区重点学科食品科学青年教师科研启动项目"HPLC法分离仙人掌总黄酮及其对急性炎症的影响"

摘　　要：为了探讨仙人掌总黄酮对小鼠的抗急性炎症作用。采用耳肿胀法、毛细血管通透性增加、足肿胀法对仙人掌总黄酮的抗急性炎症作用进行研究。结果表明：仙人掌总黄酮各剂量组小鼠耳肿胀度与空白对照组相比差异极显著（P〈0．01）；毛细血管通透性增加实验中，各剂量组的OD值与空白对照组相比差异极限著（P〈0．01）；足肿胀实验中各剂量组0．5～2h肿胀度与空白对照组相比差异极限著（P〈0．01），但各剂量组3h足趾肿胀度与空白对照组无显著差异。仙人掌总黄酮对肿胀反应及毛细血管通透性增加有显著的抑制作用，可减轻肿胀和渗出等局部炎症反应，具有一定的抗急性炎症作用。The purpose of this study is to evaluate the anti-acute inflammation effect on total flavonoids from opuntia in mice. The ear edema method, increase of capillary permeability and paw edema method were used to study the anti-acute inflammation effect on flavonoid from opuntia in mice. The results showed that the ear swelling degree in every dose group mice was significantly different compared to control mice （/9〈0.01）. The OD values in every dose group mice was significantly different from control mice in the experiment of increase of capillary permeability （P〈0.01）. The paw swelling degree at 0.5-2 h in every dose group mice was significantly different compared to control mice in the experiment of paw edema （P〈0.01）. But the paw swelling degree at 3 h was not significantly different from control group. In conclusion, opuntia total flavonoids has great inhibition on swelling reaction and increase of capillary permeability. It has the effect of deturgescence and exudation in the local inflammatory reaction, presenting anti-acute inflammation effect.

关 键 词：仙人掌 总黄酮 急性炎症 

分 类 号：R96[医药卫生—药理学]