我国中老年人N末端B型利钠肽原的正常参考值范围  

Reference value of plasma N-terminal-pro-B-type natriuretic peptide in middle-aged and elderly Chinese

作　　者：金雪娟[1] 周京敏[1] 周俊[1] 虞勇[1] 崔晓通[1] 葛均波[1] 

机构地区：[1]复旦大学附属中山医院心内科上海市心血管病研究所,200032

出　　处：《中华心血管病杂志》2013年第12期1045-1049,共5页Chinese Journal of Cardiology

基　　金：“十一五”国家科技支撑计划（2006BA101A04）;“十二五”国家科技支撑计划（2011BAI11B10）

摘　　要：目的探讨我国40岁及以上中老年人血浆N末端B型利钠肽原（NT—proBNP）的正常参考值范围。方法采用电化学发光免疫学方法，测定上海心脏健康研究（SHHS）队列基线调查中5133例健康中老年人血浆NT—proBNP水平。其中，男性2170例，女性2963例。分别采用分位数回归和经验方法估计正常参考值范围（第2．5百分位数一第97．5百分位数）。结果不同年龄段女性的NT—proBNP水平均高于男性（P均〈0．01）；无论是男性还是女性，NT—proBNP水平均随着年龄的增加而升高，NT—proBNP的自然对数与年龄呈线性相关（P均〈0．01）。分位数回归估计的NT—proBNP正常参考值范围40～44、45～49、50～54、55—59、60—64、65～69、70—74、≥75岁男性分别为4．5—86．8、5．4～108．5、6．6—135．5、7．9—169．4、9．6～211．7、11．7～264．6、14．2～330．7、18．1～429．2ng／L，女性分另0为8．5—141．8、10．4—166．6、12．8—195．7、15．7～229．9、19．3～270．1、23．7～317．3、29．1～372．8、35．7～451．9ng／L。结论本研究初步建立了我国40岁及以上中老年人血浆NT—proBNP的正常参考值范围。Objective To establish the normal ranges for plasma N-terminal-pro-B-type natriuretic peptide （NT-proBNP） of middle-aged and elderly （ ≥40 years） healthy subjects in China. Methods A total of 5133 subjects （2170 men and 2963 women） from the cohort of Shanghai Heart Health Study （SHHS） were included in this study. Plasma NT-proBNP was measured by electrochemiluminescence immunoassay. The reference values （2. 5th -97.5th quartiles ） were determined using both empiric and quantile regression methods. Results Plasma NT-proBNP values were higher in women than in men at all respective age groups（ all P 〈 0. 01 ） , and natural log-transformed NT-proBNP values increased in proportion with age for both genders and there was a lineal correlation between natural log-transformed NT-proBNP values and age （all P 〈 0. 01 ）. Quantile regression derived normal reference values for NT-proBNP in male were 4. 5 - 86. 8 ng/L in the 40 - 44 years old group, 5.4 - 108.5 ng/L in the 45 - 49 years old group, 6. 6 - 135.5 ng/L in the 50 -54 years old group, 7. 9 - 169.4 ng/L in the 55 -59 years old group,9.6 - 211.7 ng/L in the 60 - 64 years old group, 11.7 - 264. 6 ng/L in the 65 - 69 years old group, 14. 2 - 330.7 ng/L in the 70 -74 years old group, and 18.1 -429.2 ng/L in the I〉75 years old group. The reference values in female for NT-pro-BNP in respective age group were 8.5 - 141.8 ng/L, 10.4 - 166. 6 ng/L, 12. 8 - 195.7 ng/L, 15.7 - 229.9 ng/L, 19.3 - 270. 1 ng/L, 23.7 - 317.3 ng/L, 29.1 - 372.8 ng/L, and 35.7 -451.9 ng/L. Conclusion This study preliminarily establishes the normal ranges of plasma NT-proBNP in middle-aged and elderly （ ≥40 years） Chinese.

关 键 词：利钠肽 脑 参考值 中年人 老年人 

分 类 号：R446.1[医药卫生—诊断学]