血清脂蛋白脂肪酶含量与帕金森病患者不同认知损伤程度的相关性分析  

Analysis of the Correlation Between Serum Lipoprotein Lipase and Different Cognitive Impairment Extent of PD Patients

作　　者：李普蕾[1] 杨静婷[1] 恽文伟[1] 

机构地区：[1]江苏省常州市第二人民医院神经内科,江苏常州213003

出　　处：《医学临床研究》2013年第12期2328-2329,2332,共3页Journal of Clinical Research

基　　金：2012年常州市科技局立项;2012年南京医科大学科技发展基金重点项目立项（项目编号CY20120011）

摘　　要：【目的】探讨血清脂蛋白脂肪酶（LPL）水平与帕金森病（PD）患者认知损伤程度的相关性。【方法】采用简易精神状态评价量表（MMSE）与蒙特利尔认知评估（MoCA）评价PD患者认知能力，分为无认知障碍、轻度认知障碍与重度认知障碍，检测不同PD患者血清U吃水平和血脂代谢产物水平，分析LPL水平与认知损伤程度的相关性，并与90名健康体检者相关检测指标水平对照。【结果】无认知障碍的PD患者血清LPL水平与健康体检者比较无显著性差异（P〉0．05），有认知障碍的PD患者血清LPL水平较健康对照显著性下降（P〈0．05）；轻度认知障碍与重度认知障碍患者LPL水平比较无显著性差异（P〉0．05）。不同组间血脂代谢产物水平无显著性差异（P〉0．05）。【结论】血清LPL水平的降低可能与PD患者的认知能力下降有关。[Objective]To explore the correlation between serum lipoprotein lipase（LPL）and cognitive impairment extent of patients with Parkinson＇s disease（PD）. [Methods] MMSE and MoCA were used to evaluate the cognitive function of PD patients. The cognitive function was divided into no cognitive impairment, mild cognitive impairment and severe cognitive impairment. Serum LPL and blood lipid metabolites of PD patients were detected. The correlation between LPL and cognitive impairment extent was analyzed. Meanwhile, 90 healthy volunteers were collected and taken as the controls. [Results] There was no significant difference in serum LPL between PD patients without cognitive impairment and healthy controls （ P 0.05）. Compared with healthy controls, serum LDL of PD patients with cognitive impairment was markedly decreased（ P 〈0.05）. There was no significant difference in LPL between mild cognitive impairment patients and severe cognitive impairment patients（ P 〈0.05）. There was no significant difference in blood lipid metabolites among different groups. [Conclusion] The decreasing of serum LPL may be correlated with the decreasing of cognitive ability of PD patients.

关 键 词：脂蛋白类 血液 认知 

分 类 号：R341.35[医药卫生—基础医学]