重组人脑利钠肽治疗急性心肌梗死并发心功能衰竭疗效观察  

Efficacy of Recombinant Brain Natriuretic Peptide for the Treatment of Patients with Acute Myocardial Infarction Complicated by Heart Failure

作　　者：蒋建东[1] 赵祥海[1] 杨松[1] 

机构地区：[1]江苏省宜兴市人民医院心内科,江苏宜兴214200

出　　处：《医学临床研究》2013年第12期2368-2370,共3页Journal of Clinical Research

摘　　要：【目的】观察重组人脑利钠肽（rhlBNP）治疗急性心肌梗死（AMI）并发心力衰竭的疗效。【方法】50例AMI合并心力衰竭患者随机分为两组，观察组25例在常规治疗的基础上加用rh_BNP，对照组给予常规治疗，观察治疗前后两组患者临床疗效、尿量、N末端B型利钠肽原（NT—proBNP）等指标变化及心功能改善情况。【结果】治疗后观察组的总有效率显著优于对照组，且两组相比较差异有显著性（84％VS68％，P〈0．01），观察组及对照组通过治疗后，临床观察指标均有明显好转，而观察组较对照组改善更为显著。【结论】与传统药物治疗相比，rhBNP能明显改善AMI后心力衰竭患者的心功能，且不增加副作用。[Objective]To observe the efficacy of recombinant brain natriuretic peptide（rh-BNP） for the treatment of patients with acute myocardial infarction（AMI） complicated by heart failure. [MethodslA total of 50 AMI patients complicated by heart failure were randomly divided into two groups. The observation group was additionally treated with rh-BNP based on the conventional therapy, while the control group received the routine therapy. Clinical efficacy, the change of urine volume and NT-prot3NP and the improvement of cardiac function were observed before and after treatment. [ResultslAfter treatment, the total effective rate of obser- vation group was obviously better than that of control group, and there was significantly difference between two groups（ P d0. 01）. After treatment, clinical observation indicators in two groups were obviously im- proved, but the improvement of observation group was more significant than that of control group. [Conclusion] Compared with traditional drug therapy, rh-BNP can obviously improve cardiac function of patients with heart failure after AMI and not increase the side effect.

关 键 词：心肌梗死 并发症 心力衰竭 药物疗法 利钠肽 脑 治疗应用 

分 类 号：R542.22[医药卫生—心血管疾病]