海洋来源真菌Aspergillus aculeatus中一个新的具有长交叉共轭系统的甾体（英文）  

A new steroid with long cross-conjugation structure from the marine-derived fungus Aspergillus aculeatus

作　　者：王宇[1,2] 李占林[1] 刘涛[3] 田黎[4,5] 裴月湖[1] 华会明[1] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 [2]深圳市海王生物工程股份有限公司,广东深圳518057 [3]中国医科大学药学院,辽宁沈阳110001 [4]国家海洋局第一海洋研究所,山东青岛266061 [5]青岛科技大学,山东青岛266042

出　　处：《药学学报》2014年第1期68-71,共4页Acta Pharmaceutica Sinica

基　　金：Project supported by the National Natural Science Foundation of China(Grant 20872094,21002064);National High Technology Research and the Development Program of China(863 Program)(Grant No.2007AA09Z413;2007AA09Z435);Program for Innovative Research Team of the Ministry of Education;Program for Liaoning Innovative Research Team in University

摘　　要：本文对海洋来源的内生真菌棘孢曲霉(Aspergillus aculeatus)的次级代谢产物进行了研究,从其提取物中分离得到一个新的具有较长交叉共轭系统的甾体类化合物,通过各种波谱分析方法确定其结构为15α-羟基-(22E,24R)-麦角甾-3,5,8(14),22-四烯-7-酮(15α-hydroxy-(22E,24R)-ergosta-3,5,8(14),22-tetraen-7-one)。测试了该化合物在体外对小鼠白血病细胞株P388、人早幼粒白血病细胞株HL-60、人前列腺癌细胞株PC-3的细胞毒作用。A new steroid with a long cross-conjugation structure, 15a-hydroxy-（22E, 24R）-ergosta-3, 5, 8 （14）, 22-tetraen-7-one （1）, was isolated from the marine-derived fungus Aspergillus aculeatus. Its structure was established by the extensive spectroscopic analyses, and its cytotoxicities against P388, HL-60, and PC-3 cell lines were measured in vitro.

关 键 词：海洋来源真菌 棘孢曲霉 甾体 15α-羟基-(22E 24R)-麦角甾-3 5 8(14)-22-四烯-7-酮 细胞毒作用 

分 类 号：R936[医药卫生—生药学]