超声分子影像学:现状与将来  被引量:4

Ultrasound molecular imaging: current status and future

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作  者:郭燕丽[1] 范校周[1] 

机构地区:[1]第三军医大学西南医院超声科,重庆400038

出  处:《第三军医大学学报》2014年第1期6-10,共5页Journal of Third Military Medical University

基  金:国家自然科学基金面上项目(30970830);重庆市自然科学基金(CSTC 2012jjB0072)~~

摘  要:Weissleder于1999年首先阐述了分子影像学的定义,即分子影像学是通过发展新的工具、试剂及方法,应用影像学方法(X线、CT、MR、超声等)来探查疾病过程中细胞和分子水平的变化。它能使疾病在尚无解剖结构改变前被检测出来,从而有利于探索疾病的发生、发展、转归以及药物疗效的评价,Molecular imaging is to study functional molecular events in living organisms at the cellular and molecular levels through many imaging technologies,and thus to reflect the living condition at the aspect of qualitative and quantitative research. However,traditional imaging diagnostic technologies,such as X-ray radiology,CT scanning,MR imaging,and ultrasonography,etc.,mainly show anatomic structural damages. Ultrasound molecular imaging as an emerging discipline is to rely largely on the ultrasound contrast agent consisting of acoustic materials and substances binding with interesting targets,and to offer the potential and new direction for early diagnosis and targeted treatment of various diseases. Ultrasound molecular imaging has a wide prospect of clinical application due to its high soft tissue resolution,no radiation damage,no invasion,and portable instrument. The purpose of this article is to summarize the development of ultrasound contrast agent,the application in the field of ultrasound targeted diagnosis and targeted treatment,and to illustrate challenges in this field.

关 键 词:超声医学 分子影像学 造影剂 靶向治疗 多模态成像 

分 类 号:R445.1[医药卫生—影像医学与核医学]

 

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