老年男性前列腺增生与血清25-羟维生素D水平的相关性研究  

Relationship between prostatic hyperplasia and serum 25-hydroxy vitamin D level in elderly men

作　　者：郏蓉[1] 苗懿德[1] 陈陵霞[1] 刘杰[1] 褚琳[1] 魏雅楠[1] 

机构地区：[1]北京大学人民医院医院老年医学科,100044

出　　处：《中华老年医学杂志》2014年第1期59-61,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨血清25羟维生素D[25（OH）D。]与前列腺增生发生、发展的相关性。方法纳入北京大学人民医院老年科住院老年男性患者95例。测量血压、身高、体质量，计算体质指数（BMI），并检测血脂、空腹血糖（FPG）、血钙、前列腺特异性抗原（PSA）等指标，采用酶免疫分析法测定血清25（OH）D3水平。超声测量并计算前列腺体积（PV）及PV年增长率。结果95例老年男性血清25（OH）D3水平为12．1～83．9nmol／L，平均（35．5±15．2）nmol／L。血清25（OH）D3〉50nmol／L组老年男性患者PV低于25（OH）D3≤50nmol／L组[（31．5±6．0）ml与（39．9±14．5）ml，P〈0．0013；PV年增长率也低于25（0H）D3≤50nmol／L组[（o．4±0．2）ml／年与（O．5±0．4）ml／年，P〈0．013。相关分析结果显示，PV与血清25（OH）D3呈负相关（r=-0．207，P=0．044），与BMI、PSA呈正相关（r值分别为0．297、0．958，P=0．011和P〈0．001）；PV年增长率也与BMI、PSA呈正相关（r值分别为0．316、0．464，p-0．007和P〈O．001），与血清25（OH）D。呈负相关，但差异无统计学意义（P〉0．05）。结论低水平血清25（OH）D。可能是前列腺增生的危险因素。Objective To explore the relationship between serum 25-hydroxy vitamin D level and prostatic hyperplasia in elderly men. Methods Totally 95 male patients aged over 60 years were included. Blood pressure, body weight, body height, body mass index （BMI） were measured and calculated. Venous blood samples were obtained to determine fasting serum levels of 25-hydroxy vitamin D3 and blood glucose （FBG）, total cholesterol （TC）, triglycerides （TG）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, calcium and prostate specific antigen （PSA）, total prostate volume（PV） and annual prostate growth rate were measured and calculated by ultrasound. Results The serum 25 （OH） D3 levels were varied from 12.1 nmol/ L to 83.9 nmol/L, with an average of （35.5±15.2） nmol/L in elderly male patients. PV growth rate were significantly lower in elderly men with 25 （OH） D3 〉50 nmol/L, than in elderly men with 25 （OH） D3≤50 nmol/L [（31.5±6.0） mlvs. （39.9 ± 14.5） ml, （0.4± 0.2） ml/yvs. （0.5 ± 0.4） ml/y, P〈0. 001 or 0.01]. PV was negatively correlated with serum 25-hydroxy vitamin D3 level （r= -0. 207, P〈0.05）, and positively correlated with BMI and PSA （r=0. 297, 0. 958, P〈0.05 or and P〈0. 001）. While annual prostate growth rate was positively correlated with BMI and PSA （r= 0. 316, 0. 464, P〈0.01 or d0. 001）, and positively correlated with serum 25-hydroxy vitamin D3 level, but the difference was not statistically significant （P〉0.05）. Conclusions I.ow serum 25- hydroxy vitamin D3 level may play a role in the pathogenesis of prostatic hyperplasia.

关 键 词：前列腺增生 维生素D 

分 类 号：R697.3[医药卫生—泌尿科学]