吸烟对血浆尿酸水平的影响  

Effect of cigarette smoking on plasma uric acid concentrations

作　　者：王玉兰[1] 刘斌[2] 马丽娜[1] 王蓉[1] 

机构地区：[1]首都医科大学宣武医院中心实验室,北京市老年病医疗研究中心,北京100053 [2]首都医科大学附属北京友谊医院检验科,北京100050

出　　处：《首都医科大学学报》2013年第6期856-859,共4页Journal of Capital Medical University

基　　金：北京市自然科学基金(7132044);首都卫生发展科研专项(首发2011-2001-02)~~

摘　　要：目的测定吸烟对血浆尿酸的影响及其与烟草代谢物的关系。方法选取健康体检者300例,其中吸烟者162例(男性145例,女性17例),不吸烟者138例(男性62例,女性76例),测定血浆尿酸、肌酐以及尿可替宁水平。结果吸烟者血浆尿酸水平较不吸烟者明显降低,差异有统计学意义。血浆尿酸水平与吸烟量、吸烟时间呈负相关。结论在排除影响血浆尿酸的因素以后,吸烟者尿酸水平较不吸烟者明显降低,且这种降低与尿酸内源性生成减少有关,是吸烟促发人体应激反应作用的结果。由于血浆尿酸测定方法简单,而且能反映人体的抗氧化物水平,因此它有可能作为了解吸烟应激状态的常规测定指标。Objective The purpose of this study was to examine the effect of cigarette smoking on plasma uric acid concentration and to determine the correlation between this parameter and the biological tobacco markers, urinary cotinine. Methods The study was conducted on 300 subjects. One hundred and thirty-eight of them were nonsmokers（62 men and 76 women） and 162 were current smokers （145 men and 17 women）. Uric acid, creatinine, and urinary cotinine were determined by the enzymatic colorimetric method. Results Plasma uric acid concentration was significantly lower in smokers than in nonsmokers. A statistically significant negative correlation was noted between the smoking status parameters, including both the number of cigarettes smoked/day and the duration of smoking, and the plasma uric acid. Among smokers, we noted a negative correlation between uric acid, and urinary cotinine. Conclusion After excluding the other factors affecting the uric acid levels, the significant low plasma uric acid in smokers was attributed to a reduction of the endogenous production as a result of the chronic exposure to cigarette smoke that is a significant source of oxidative stress. Therefore, it is recommended to stop or reduce smoking and to introduce plasma uric acid estimation as a routine test, since it is cheap and simple to reflect the antioxidant level.

关 键 词：吸烟 可替宁 尿酸 氧化应激 

分 类 号：R589.2[医药卫生—内分泌]