声强对下丘神经元时间分辨率的影响  

The Effects of Sound Intensity on Temporal Resolution in Inferior Colliculus Neurons

作　　者：和守睆 Awad M Almuklass 王坚 金晓杰 

机构地区：[1]上海市中山医院青浦分院耳鼻咽喉科,上海201700 [2]沙特Abdulaziz国王健康科学大学医学院基础医学部,riyadh沙特阿拉伯11426 [3]加拿大Dalhousie大学人类交流障碍学院 [4]上海市仁济医院耳鼻咽喉头颈外科,上海200127

出　　处：《中华耳科学杂志》2013年第4期588-592,共5页Chinese Journal of Otology

基　　金：加拿大国家自然科学与工程研究所基金(NSERC):RG PIN/250088-2007

摘　　要：目的探讨声强对豚鼠下丘相位型神经元时间分辨率的影响。方法选取40只健康成年豚鼠,采用单细胞记录的方法,刺激信号为含有一定时间间隔的两段白噪声,其时间间隔分别为0、1、2、3、6、9、12、24、48和96ms。分别观察阈上15、35和55dB对豚鼠下丘相位型神经元的最小间隔阈值、间隔后放电恢复率及首次放电潜伏期的影响。结果共记录到166个神经元,本研究仅观察相位型神经元,共计90个。不同声强刺激时,下丘相位型神经元的最小间隔阈值无明显差异,分别为8.81±1.08ms、7.08±0.78ms和7.11±0.67ms。不同声强刺激时,下丘相位型神经元的间隔后放电恢复率无明显差异。不同声强刺激时,下丘相位型神经元的首次放电潜伏期有统计学差异,分别为7.28±0.15ms、5.75±0.14ms和5.05±0.13ms。结论声强对豚鼠下丘相位型神经元的时间分辨率无明显影响,神经元响应随声强的提高而加快。Objective To study effects of sound intensity on temporal resolution in phasic neurons in the inferior collicu- lus （IC）. Methods Single unit recording was conducted in 40 adult guinea pigs. Gap stimuli was created by two Gaussian noise bursts that were separated by different gap durations： 0, 1, 2, 3, 6, 9, 12, 24, 48 and 96 ms. The minimal gap threshold （MGT） as well as NB2 recovery and first spike latency （FSL） were analyzed under the following sound intensity exposures： minimum threshold （MT） ±15 dB, MT±35 dB and MT±55 dB. Results Totally 166 neurons were recorded and data from 90 phasic neu- rons were presented. MGT was 8.81±1.08 ms, 7.08±0.78 ms and 7.11±0.67 ms, and FSL was 7.28±0.15 ms, 5.75±0.14 ms and 5.05±0.13 ms for the three sound intensities respectively. There was no significant difference in MGT, FSL or NB2 recovery among the three groups. Conclusion Sound intensity appears to have no significant effect on temporal resolution of IC phasic neurons in guinea pigs, although the neuron response time shortens as sound intensity increases.

关 键 词：声强 下丘 时间分辨率 豚鼠 

分 类 号：R352[医药卫生—基础医学] R338