骨质疏松症发生与防治的线粒体机制  

Mitochondrial Mechanism in Occurrence,Prevention and Treatment of Osteoporosis

作　　者：高静[1] 龙建纲[1] 刘健康[1] 

机构地区：[1]西安交通大学生命科学与技术学院线粒体生物医学研究中心,陕西西安710049

出　　处：《航天医学与医学工程》2013年第6期491-494,共4页Space Medicine & Medical Engineering

基　　金：国家自然科学基金项目(31370844);航天医学基础与应用国家重点实验室开放基金资助项目(SMFA10K07)

摘　　要：骨质疏松与衰老及许多代谢性疾病密切相关。绝经后妇女体内雌激素水平下降,糖皮质激素类药物的使用,以及航天飞行的失重效应均可诱导骨质疏松症的发生。氧化应激是骨质疏松发生的重要机制,自由基通过调控信号通路或诱发炎症反应影响成骨细胞及破骨细胞的分化、功能和凋亡,而抗氧化剂能有效预防和治疗骨质疏松症。线粒体作为细胞内能量代谢与氧化应激发生的主要部位,在骨质疏松的发生机制中发挥着重要作用,可能是防治骨质疏松症的新靶点。Osteoporosis is closely related to aging and metabolic disease. Low estrogen level of postmenopaus- al women, use of glucocorticoids, and weightlessness effects in space flight can cause osteoporosis. Oxidative stress is the important mechanism in osteoporosis occurrence. The free radical adjusts the signal pathway or in- duces inflammation to affect the differentiation, function and apoptosis of osteoblast and osteoclast. Some of antioxidants can prevent and cure osteoporosis effectively. Mitochondria, as the major cell organelle in energy metabolism and oxidative stress occurrence, play an important role in pathogenesis of osteoporosis, and may be a new promising target for osteoporosis chemoprevention and treatment.

关 键 词：骨质疏松 氧化应激 抗氧化剂 线粒体 线粒体营养素 

分 类 号：R681[医药卫生—骨科学] R854[医药卫生—外科学]