新疆喀什地区人群内脏利什曼病血清流行病学调查  

Serological investigation of the prevalence of visceral leishmaniasis in Kashgar,Xinjiang,China

作　　者：王立英[1] 曾祥嫚[1] 伍卫平[1] 付青[1] 童苏祥[2] 侯岩岩[2] 伊斯拉音.乌斯曼 凯赛尔 官亚宜[1] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,卫生部寄生虫病原与媒介生物学重点实验室,上海200025 [2]新疆维吾尔自治区疾病预防控制中心 [3]新疆维吾尔自治区喀什地区疾病预防控制中心

出　　处：《中国病原生物学杂志》2013年第12期1121-1123,共3页Journal of Pathogen Biology

基　　金：国家科技重大专项(No.2012ZX10004-220,No.2008ZX10004-011);国家传染病重大专项(No.2012ZX10004-201,No.2009ZX10004-201)

摘　　要：目的通过对新疆喀什人源型内脏利什曼病流行区人群进行血清流行病学调查,掌握当地人群内脏利什曼病的感染状况和影响因素。方法在喀什地区伯什克拉姆乡的3个大队采用系统抽样的方法抽取住户,采用Ka24单抗抑制ELISA法测定居民血清抗利什曼前鞭毛体可溶性抗原Ka24抗体。结果调查1 642人,人群内脏利什曼病血清学阳性302人,阳性率为18.39%;既往利什曼病病人血清学阳性率为48.76%(59/121),无病史者阳性率为15.98%((243/1 521)),差异有统计学意义(χ2=80.26,P<0.01)。距发病时间越近,检测的阳性率越高(χ2=11.55,P<0.01)。而不同性别、不同职业和不同年龄利什曼病患者血清学阳性率差异无统计学意义(P>0.05)。结论新疆喀什人群利什曼病血清学阳性率较高,该地区仍为利什曼病流行较为严重的地区,需加强防治力度。Objective To conduct a seroepidemiological study to ascertain the state of and risk factors for visceral leishmaniasis in Kashgar, Xinjiang. Methods Residents of three villages in the Township of Boshikeranmu were selected by systematic sampling. ELISA with the Ka24 antigen was used to detect antibodies against that antigen. Results Specimens were serologically positive at a rate of 18. 39% （302/1 642）. Specimens were serologically positive at a rate of 48.76% （59/121） in residents who previously had visceral leishmaniasis and 15.98% （243/1 521） in residents who had never had visceral leishmaniasis. The difference in the seropositive rate was significant. The closer to the onset of visceral leishmaniasis, the higher the rate at which individuals tested serologically positive （Х^2 = 11.55, P〈0.01）. There were no significant differences in the seropositive rate for either sex or in terms of occupation or age （P〉0.05）. Conclusion Individuals in Xinjiang tested serologically positive for visceral leishmaniasis at a high rate. More work needs to be done to control visceral leishmaniasis.

关 键 词：利什曼病 ELISA法 血清学调查 喀什 新疆 

分 类 号：R531.6[医药卫生—内科学]