S-烷基O-芳基硫代磷酸衍生物的合成及其杀虫活性的研究  

Studies on the Synthesis and Insecticidal Activities of S-Alkyl O-Aryl Thiophosphoric Derivatives

作　　者：唐除痴[1] 吴桂萍[1] 张根柱 陈学仁[1] 毕富春[1] 王文丽[1] 朱兰惠[1] 

机构地区：[1]南开大学元素有机化学研究所,天津300071

出　　处：《高等学校化学学报》1991年第11期1478-1482,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：研究了O,O-二烷基O-芳基硫代磷酸酯与三氧氧磷的异构化氯化反应。由此生成的S-烷基O-芳基硫代磷酰再与亲核试剂(醇,酚,硫醇,硫酚,伯胺或氨)在缚酸剂存在下反应,合成了42种化合物,其中34种未见文献报道。本文还研究了这类化合物的杀虫活性。Forty-two compounds, among them thirty-four new compounds of S-alkyl O-aryl thiophosphoric derivatives have been synthesized by using a new convenient method which is based on the isomerization-chlorination of O,O-dialkyl O-aryl phosphorothionate with phosphoryl chloride to give S-alkyl O-aryl thiophosphorochloride. Then, this thiophosphorochloride reacts with various nucleophiles, e. g. alcohol, phenol, mercaptan, thiophenol, ammonia, amine, in the presence of acid-binding agent to obtain S-alkyl O-aryl thiophosphoric derivatives, e. g. S-alkyl O-alkyl (or aryl) O-aryl phosphorothiolate, S-alkyl S-alkyl (or aryl) O-aryl phospho-rodithiolate, S-alkyl O-aryl phosphorothiolamide. The insecticidal activities of the compounds prepared towards bean aphid (Aphis laburni), cotton red spider (Tetranychus telarius), army worm(Leucania separata) and house fly (Musca domestica) have also been tested.

关 键 词：硫代磷酸酯 异构化 氯化 杀虫活性 

分 类 号：TQ453.22[化学工程—农药化工]