肥大细胞Toll样受体在支气管哮喘中的作用研究进展  

Expression of Toll-like receptors in mast cell in the role of bronchial asthma research progress

作　　者：李艳[1,2] 黄克武[1] 孙英 王炜[2] 

机构地区：[1]首都医科大学附属北京朝阳医院呼吸与危重症医学科北京呼吸疾病研究所,100020 [2]首都医科大学基础医学院免疫学系,北京100069 [3]London SE19RT Division of Asthma,Allergy & Lung Biology,King's College London,Medical Research Council & Asthma United Kingdom Centre in Allergic Mechanisms of Asthma

出　　处：《中华哮喘杂志（电子版）》2013年第6期50-53,共4页Chinese Journal of Asthma(Electronic Version)

基　　金：国家自然科学基金(81102250);北京市教育委员会科技发展计划面上项目(KM201010025002;KM201110025005);北京市属高等学校人才强教深化计划"中青年骨干人才培养计划"项目(PHR201008382);教育部博士点基金(20101107110003);北京市卫生系统高层次卫生技术人才培养计划项目(2011-2-04)资助;中华医学会临床科研专项基金(08020410119)

摘　　要：支气管哮喘是一种慢性气道炎症性疾病,其病理生理特征主要表现为可逆性的气流受限和气道高反应性。其中嗜酸粒细胞、肥大细胞、中性粒细胞等是气道炎症的主要效应细胞。本文介绍了肥大细胞的来源、分型以及活化后释放的介质种类。重点综述了肥大细胞上Toll样受体的种类、作用以及在支气管哮喘的发生发展中的作用。Bronchial asthma （asthma） characterized clinically by reversible airway is a chronic inflammatory disease of the lower airways, obstruction and airway hyperresponsiveness （AHR）. Eosinophils, mast cells and perhaps neutrophils are the major effector cells participated in the airways inflammation. In the present article, we have attempted to review the Origin and subtypes of mast cells, as well as biological mediators released by activated mast cells. We focused on the types and roles of Toll- like receptors expressed by mast ceils, which are potentially involved in the pathogenesis of bronchial asthma.

关 键 词：肥大细胞 TOLL样受体 哮喘 

分 类 号：R392.11[医药卫生—免疫学]