头孢西丁钠在不同输液中的不溶性微粒观察  

Observation on Insoluble Particles in Compatibility of Cefoxitin and Different Common Solvents

作　　者：郭冰[1] 

机构地区：[1]苏州市第五人民医院药剂科,江苏苏州215007

出　　处：《中外医疗》2013年第36期19-20,共2页China & Foreign Medical Treatment

摘　　要：目的探讨观察头孢西丁钠与5%葡萄糖注射液、0.9%氯化钠注射液和替硝唑氯化钠注射液配伍时不溶性微粒的变化。方法模拟临床输液配伍,将头孢西丁钠分别加入5%葡萄糖注射液、0.9%氯化钠注射液和替硝唑氯化钠注射液中,测定配伍液中6 h内不溶性微粒的变化。结果头孢西丁钠与以上输液配伍后6 h内,各配伍液外观无明显变化,但配伍后≥10μm和≥25μm的不溶性微粒均有明显增加,但符合《中国药典》的要求。结论对头孢西丁钠配伍后不溶性微粒增加可能导致的不良反应应予以注意。Objective To study the changes of insoluble particles from cefoxitin mixed with 5% glucose injection, 0.9% sodium chloride injection and tinidazole injection, respectively. Methods The cefoxitin was mixed with 5% glucose injection and 0.9% sodium chloride injection and tinidazole injection respectively according to its clinical usage,and the changes of insoluble particles in the cefoxitin solutions in 6 hours after mixing were measured by a particles analyzer. Results Within 6 hours after the compatibility, the appearances of the cefoxitin solutions had no obvious change, bat the amount of the insoluble particles equal to, or bigger than 10 M and 25 M increased to the extent which was permitted by the requirement for IV injection according to Chinese Pharmacopoeia. Conclusion The adverse effects induced by the increase of insoluble particles in cefoxitin mixed with the above three solutions should not be ignored.

关 键 词：头孢西丁钠 不溶性微粒 配伍 

分 类 号：R4[医药卫生—临床医学]