5-甲基色胺衍生物的合成  

Synthesis of 5-Methyltryptamine Derivatives

作　　者：朱海峰[1] 陆海晶[1] 余肖平 梁洪泽[1] 金海晓[1] 周雄[1] 

机构地区：[1]宁波大学材料科学与化学工程学院,浙江宁波315211

出　　处：《宁波大学学报（理工版）》2014年第1期80-83,共4页Journal of Ningbo University：Natural Science and Engineering Edition

基　　金：国家自然科学基金(20903058);宁波市自然科学基金(2010A610027);宁波大学王宽诚基金

摘　　要：以5-甲基色胺盐酸盐和邻溴苯乙酸为例,研究了5-甲基色胺衍生物的合成方法.在室温下用二环己基碳二亚胺(DCC)作为脱水剂,N-羟基琥珀酰亚胺(NHS)活化酯法一锅法合成5-甲基色胺衍生物,并通过FTIR、MS、1H NMR、13C NMR确定了目标化合物结构.The synthetic method of 5-methyltryptamine derivatives has been studied using 5-methyltryptamine hydrochloride and 2-bromophenylacetic acid as the test compounds. The results show that by combining dicyclohexylcarbodiimide（DCC） as a condensation reagent, and N-hydroxysuccinimide（NHS） as an activating reagent, a series of amides based on 5-methyltryptamine and substituted phenylacetic acids are synthesized with high yields at room temperature in one pot procedure. The structures of all the products are confirmed by FTIR, MS, ^1H NMR and ^13C NMR spectra.

关 键 词：5-甲基色胺盐酸盐 酰胺 N-羟基琥珀酰亚胺 

分 类 号：O622.6[理学—有机化学]