探讨纳洛酮在救治中度、重度有机磷中毒中的疗效  

curative effect of naloxone in the treatment of severe organophosphorus poisoning

作　　者：凌进华[1] 

机构地区：[1]安徽省黄山市人民医院急诊科,安徽黄山245000

出　　处：《吉林医学》2014年第1期21-23,共3页Jilin Medical Journal

摘　　要：目的:探讨纳洛酮在中度、重度有机磷中毒患者救治中的疗效。方法:选择57例符合入选条件的有机磷中毒患者,随机分为纳洛酮治疗组(30例)和对照组(27例),两组常规治疗相同,纳洛酮组常规治疗同时静脉推注纳洛酮2 mg,1次/2 h直至清醒或症状缓解。观察长托宁化时间、清醒时间、平均住院日、存活例数。结果:治疗组长托宁化时间、清醒时间、平均住院日均明显优于对照组,差异均有统计学意义(P<0.05,t=23.28、14.34、10.46),存活例数两组差异无统计学意义(P>0.05,χ2=0.018 6)。结论:在中度、重度有机磷中毒救治中使用纳洛酮能缩短长托宁化时间、清醒时间、平均住院日,但对出院成活率没有明显影响。Objective To evaluate the efficacy of naloxone in the treatment of moderate and severe organophosphate poisoning.Method 57 cases of patients who met the inclusion criteria were reviewed.And patients with organophosphate poisoning were randomly allocated to two groups,the naloxone group（ n=30） and the normal group（ n=27）.The two groups received the same basic treatment and the naloxone group was given additional treatment with 2.0 mg Naloxone-intravenous injection every two hours till consciousness recovering or symptoms improved.Observed the time of Penehyclidine change,sober time,the average length of stay,survived number of cases.Results the time of Penehyclidine change,sober time,the average length of stay of the treatment group were significantly better than those of control group,had a statistically significant difference（ P〈0.05,t=23.28,t=14.34,t=10.46）,survival number of cases of the two groups showed no significant differences（ P〈0.05,χ^2= 0.018 6）.Conclusion The use of naloxone in the treatment of moderate and severe organophosphate poisoning can shorten the time of Penehyclidine change,sober time,the average length of stay,but has no significant effect on hospital discharge survival rate.

关 键 词：纳洛酮 有机磷中毒 清醒时间 平均住院日 

分 类 号：R595.4[医药卫生—内科学]