骨性关节炎患者中血清与关节液的炎性因子水平变化及意义  

Changes of Inflammatory Cytokine Levels in Serum and Synovial Fluid of Osteoarthritis Patients

作　　者：陈根强[1] 许慧娟[1] 汪志明[2] 马华膺[2] 

机构地区：[1]金华职业技术学院,浙江金华321017 [2]浙江省金华市中心医院骨科,浙江金华321000

出　　处：《武汉大学学报（医学版）》2014年第1期110-113,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨骨性关节炎患者中血清与关节液的炎性因子水平变化及在骨性关节炎的发病中的意义。方法:选择我院2009年3月-2011年3月60例骨性关节炎患者及体检中心60例健康自愿者作为正常对照,通过X线分为早、中、晚期,分别检测血清及关节液中IL-1、IL-6、IL-8、IL-10及TNF-α浓度。结果:与对照组相比较,实验组中血清以及关节液的IL-1、IL-6、IL-8、IL-10及TNF-α的均随病程加重而显著升高。并且IL-1、IL-6及TNF-α能有效体现骨性关节炎的严重程度。结论:炎性细胞因子参与了骨性关节炎的形成和进展,IL-1、IL-6以及TNF-α对于骨性关节炎的严重程度是有效的指标。Objective： To investigate changes of inflammatory cytokines and their clinical value in osteo- arthritis. Methods： Sixty patients with osteoarthritis and 60 normal subjects as controls were ob- served from March 2009 to March 2011. TNF-α, IL-1, IL-6, IL-8, and IL-10 in serum and joint fluid were measured and compared among normal subjects and osteoarthritis patients in different stages. Results： The serum concentration of TNF-α, IL-1, IL-6, IL-8, and IL-10 in experimental group were significantly increased along with the severity of osteoarthritis. The increase of TNF- α, IL-1, and IL-6 concentration in joint fluid was more apparent than in serum. Conclusion： The inflammatory cytokines are involved in the formation and progression of osteoarthritis liquid, and TNF-α, IL-1, and IL-6 levels in synovial fluid could be used as predictors for osteoarthritis severity.

关 键 词：骨性关节炎 炎性因子 炎症反应 

分 类 号：R684.1[医药卫生—骨科学]