慢性肾脏病晚期肾性贫血患者可溶性转铁蛋白受体水平变化及意义  

Changes and significance of serum soluble transferrin receptor in advanced renal anemia in patients with chronic kidney disease

作　　者：杜银科[1] 刘林林[1] 姚丽[1] 王娟[1] 朱新旺[1] 孙达[1] 王力宁[1] 

机构地区：[1]中国医科大学附属第一医院肾内科,沈阳110001

出　　处：《中华实用诊断与治疗杂志》2014年第1期46-47,共2页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨血清可溶性转铁蛋白受体（solubletransferrinreceptor，s—TfR）水平在慢性肾脏病（chronickidneydisease，CKD）晚期肾性贫血患者中的临床意义。方法CKD4～5期患者60例，测定血清s—TfR、铁蛋白、铁、转铁蛋白等指标水平，计算肾小球滤过率和转铁蛋白饱和度，比较CKD4期与5期患者铁状态评估指标的差异，分析s—TfR与铁蛋白及转铁蛋白饱和度的相关性。结果CKD4期患者铁蛋白、转铁蛋白饱和度明显高于5期患者，而s—TfR明显低于5期患者（P均〈0．05）；s—TfR与铁蛋白及转铁蛋白饱和度呈负相关（r=-0．398，P〈0．05；r=-0．817，P〈0．01）。结论CKD5期患者铁缺乏状态较CKD4期患者严重。Objective To investigate the significance of serum soluble transferrin receptor （s-TfR） in advanced renal anemia in patients with chronic kidney disease （CKD）. Methods Sixty patients with CKD stage 4 to 5 were detected serum s-TfR, serum ferritin, serum iron and transferrin, and were calculated glomeru[ar filtration rate （GFR） and transferrin saturation. The indicators of iron status were compared between the patients with CKD stage 4 and CKD stage 5. The correlation of s-TfR with serum ferritin and transferrin saturation was analyzed. Results The levels of serum ferritin and transferrin saturation were significantly higher, and the level of s-TfR was significantly lower in CKD stage 4 than that in CKD stage 5 （P〈0.05）. s-TfR was negatively correlated with serum ferritin and transferrin saturation （r= -0. 398, P〈0.05; r=-0. 817, P〈0.01）. Conclusions The status of iron deficiency is much severer in patients with CKD stage 5 than that in patients with CKD stage 4. s-TfR can be used as one of the reliable indicators for evaluating the status of iron deficiency in advanced renal anemia in patients with CKD.

关 键 词：慢性肾脏病 可溶性转铁蛋白受体 缺铁性贫血 铁蛋白 转铁蛋白饱和度 

分 类 号：R692[医药卫生—泌尿科学]