安徽省安庆地区卡波肉瘤相关疱疹病毒感染的危险因素分析  

Seroprevalence and risk factor of Kaposi's sarcoma-associated herpesvirus in Anqing,Anhui province

作　　者：段强[1] 张莹[2] 曾宪聪[2] 汪小五[2] 吴悦[2] 杜爱能 刘璐璐[2] 陈振[2] 刘淑均[3] 李进 王林定[2] 

机构地区：[1]安庆市第一人民医院输血科,安庆246003 [2]安徽医科大学微生物学教研室,合肥230032 [3]安徽医科大学第一附属医院输血科,合肥230022 [4]合肥市蜀山区疾病预防控制中心检验科,合肥230039

出　　处：《安徽医科大学学报》2014年第1期44-47,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81271837);安徽省教育厅自然科学基金(编号:KJ2012A161);安徽医科大学博士科研经费资助项目(编号:XJ200914)

摘　　要：目的探讨安徽省安庆地区卡波肉瘤相关疱疹病毒(KSHV)在普通人群中的感染情况,并初步分析KSHV感染的危险因子。方法选择KSHV ORF65、ORF73和K8.1编码的病毒蛋白为抗原,采用酶联免疫法对1 006份普通健康人群血清进行KSHV抗体检测。结果在检测的1 006份血样中,KSHV抗体的总阳性率为5.3%,其中男性为5.6%,女性为5.5%。KSHV感染率与梅毒感染有显著相关性,但是其与年龄、性别、血型及乙肝五项间无明显相关性。结论中国安徽安庆地区的普通健康人群KSHV的感染率较低,其中KSHV的感染率与性病梅毒感染具有显著相关性。Objective To obtain KSHV seroprevalence in the general population in Anqing, Anhui province. Methods In this study, antibodies to one latent protein of KSHV （ ORF73 ） and two KSHV lytic proteins （ ORF65 and ORF-K8.1 ） were tested by ELISA. Results Of the 1 006 subjects, the seroprevalence of KSHV in the general population was 5.3% , and similar in male and female subjects （5.6% vs 5.5% ）. Statistical analysis showed that seroprevalence of KSHV had a significant association with Syphilis, but it had no differences in the age, sex, blood type and hepatitis B antigen. Conclusion These results indicate that the seroprevalence of KSHV is low in the south of Anhui Province. The seroprevalence of KSHV has a significant difference between Syphilis.

关 键 词：卡波肉瘤相关疱疹病毒 血清阳性率 危险因素 

分 类 号：R373.4[医药卫生—病原生物学]