合肥地区唐氏综合征筛查中位数方程的研究  

The research of median equation for Down's syndrome screening in Hefei

作　　者：许晓红 刘辉 黄大雁 李子贤 邓松华[2] 

机构地区：[1]安徽省妇幼保健院检验科,合肥230001 [2]安徽医科大学病理生理学教研室,合肥230032

出　　处：《安徽医科大学学报》2014年第1期47-50,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学重点科研项目(编号:KJ2010A177);合肥市科技局科研项目(编号:201231);合肥市医学重点学科建设计划资助

摘　　要：目的以数据分析软件拟合合肥地区孕中期母血清标志物中位数方程,并评价新方程的效果。方法取合肥地区33 638例孕妇的产前筛查数据,以SPSS 17.0拟合新中位数方程,比较新中位数与2T-Risk软件内嵌中位数,计算风险结果,比较筛查效率。结果新中位数方程与内嵌中位数有差异,更换中位数后,筛查效率提高。结论用数据分析软件拟合本实验室中位数方程可以提高筛查效率,此中位数方程对合肥地区产前筛查有指导意义。Objective To detect the median equation of maternal serum markers with second trimester gestation in Hefei, and to evaluate the effect of the new equation. Methods The maternal serum markers of 33 638 women were involved in this study. The new median equation was calculated through SPSS 17.0 and the difference between new median and data of 2T-risk were also evaluated. The individual risk assessment was established to verify antepartum risk screening results. Results The new median equation was superior to data of 2T-risk which effectively reduced the birth defects. Conclusion Screening efficiency can be improved by re-calculation of median, and the new median equation has very important significance to the prenatal screening in Hefei.

关 键 词：产前筛查 甲胎蛋白 游离β-人绒毛膜促性腺激 素 中位数 

分 类 号：R714.55[医药卫生—妇产科学]