母亲接种麻疹疫苗对婴儿首针麻疹疫苗免疫效果的影响  

Evaluation on the influence of mothersr measles vaccination before pregnancy on the immune effect of infantrs first-dose measles vaccination

作　　者：李永成[1] 高志刚[1] 张颖[1] 张之伦[1] 曲江文[1] 丁亚兴[1] 田宏[1] 陈德荣[2] 刘明珠[3] 王现玲 王德玲[5] 

机构地区：[1]天津市疾病预防控制中心免疫规划科,300011 [2]天津市红桥区疾病预防控制中心免疫规划科 [3]天津市红桥医院预防科 [4]天津市南开区疾病预防控制中心免疫规划科 [5]天津市第一中心医院妇产科

出　　处：《中华传染病杂志》2014年第1期18-21,共4页Chinese Journal of Infectious Diseases

基　　金：天津市厅局级重点科技基金项目（2010KR07）

摘　　要：目的评价母亲接种麻疹疫苗后对婴儿首针麻疹疫苗免疫成功率的影响，了解孕妇和婴儿的麻疹抗体水平及其关系。方法按照近10年内母亲是否接种含麻疹成分疫苗选择研究对象，追踪监测孕妇分娩前、新生儿出生时、婴儿8月龄免疫前和接种疫苗后1个月的麻疹IgG抗体水平，采用ELISA法检测。抗体效价〉200mIU／mL为阳性，〉1000mIU／mL为保护性抗体水平阳性。采用t检验和卡方检验。结果共调查107对研究对象，其中接种疫苗组41对，未接种疫苗组66对。母亲接种疫苗组新生儿麻疹保护性抗体阳性21名，占51．2％，未接种疫苗组阳性19名，占28．8％（χ2=5．436，P=0．020）；新生儿麻疹保护性抗体几何平均效价（GMC）分别为735．3和566．7mIU／mL（t’=2．064，P=0．043）；两组分别检测36名和60名免疫前后的婴儿，母亲接种疫苗组首针免疫成功率为91．7％，未接种疫苗组为90．0％（校正χ2=0．075，P=0．785）；免疫后1个月麻疹保护性抗体GMC分别为1055．6N926．0mIU／mL（F1．648，P=0．103）。结论母亲接种含麻疹成分疫苗后不影响8月龄婴儿首针麻疹疫苗的免疫成功率和抗体效价，能提高孕妇和新生儿麻疹保护性抗体阳性率，抗体效价也显著增高。Objective To evaluate the influence of mothers＇ measles vaccination on the success rate of infants＇ first-dose measles vaccination and to access the relationship between mothers＇ anti-measles antibody levels and their infantsr. Methods The recruited pregnant women were divided into two groups according to their measles vaccination history in recent 10 years, and their anti-measles IgG antibody levels were detected by enzyme-linked immunosorbent assay （ELISA）. The anti-measles antibody levels of the corresponding infants were detected by ELISA at birth, 8-months after birth （before measles vaccination） and one month after measles vaccination. The concentration of anti-measles IgG antibody 〉200 mIU/mL was considered as seropositive, and 1 000 mIU/mL was considered as protective level. Chi square test and t test were used for statistical analysis. Results A total of 107 pairs of objects were included in this study, with 41 pairs in vaccinated group and 66 pairs in non-vaccinated group. The rates of newborn infants whose anti-measles antibody reached protective level in vaccinated group and non-vaccinated group were 51.2% and 28. 8%, respectively （ 2 =5. 436, P=0. 020）. And the geometric mean concentrations （GMC） of anti-measles antibody in the two groups were 735.3 mIU/mL and 566.7 mIU/mL, respectively （t＇=2. 064, P= 0. 043）. The success rates of infants＇ first-dose measles vaccination in the two groups were 91.7% and 90.0%, respectively （χ2 =0. 075, P=0. 785）. One month after vaccination, the GMC were 1 055.6 mIU/mL and 926.0 mIU/mL, respectively （t= 1. 648, P= 0. 103）. Conclusions Using measles containing vaccine in reproductive women dose not influence the success rate of infants＇ first-dose measles vaccination 8-months after birth and does not influence the concentration of anti-measles antibody produced one month after vaccination. However, mothers＇ measles vaccination can increase the protective antibody levels in their infants.

关 键 词：麻疹疫苗 接种 母亲 婴儿 抗体 病毒 免疫 主动 

分 类 号：R186[医药卫生—流行病学]