CD64指数在鉴别系统性红斑狼疮继发感染和病情活动中的意义  

Significance of CD64index in differentiation of secondary infection and disease activity in patients with systemic lupus erythematosus

作　　者：尤海燕[1] 裘影影[2] 吴玲[2] 王蓓[1] 邹晓月[1] 

机构地区：[1]江苏大学附属医院检验科,212001 [2]江苏大学附属医院风湿科,212001

出　　处：《江苏医药》2014年第1期53-55,共3页Jiangsu Medical Journal

基　　金：江苏大学临床医学科技发展基金资助项目(JLY2010119)

摘　　要：目的探讨CD64指数在鉴别系统性红斑狼疮(SLE)继发感染和病情活动中的意义。方法 87例SLE患者分为细菌感染组(A组,32例)和非细菌感染组(B组,55例);后者依SLE疾病活动性指数(SLE DAI)分为SLE活动组(B1组,SLE DAI≥8分,25例)与SLE稳定组(B2组,SLE DAI<8分,30例)。另设健康对照组(C组,30例)。采用流式细胞术检测外周血中性粒细胞、单核细胞及淋巴细胞表面CD64的平均荧光强度,计算出CD64指数,与感染指标和病情活动指标进行相关性分析。结果 A组CD64指数显著高于B1组、B2组和C组(7.90±3.43vs.2.44±0.98、1.49±0.64和1.45±0.61)(P<0.01)。A组CD64指数与WBC数、中性粒细胞数、血沉、C反应蛋白、降钙素原水平呈显著正相关(r=0.483,r=0.535,r=0.601,r=0.676,r=0.724,P<0.01),而与SLE DAI、抗核抗体、抗ds-DNA抗体、补体3、补体4水平之间均无显著相关性(P>0.05);B1组CD64指数与上述所有指标间皆无显著相关性(P>0.05)。结论 CD64指数可作为SLE继发细菌感染和病情活动的鉴别指标。Objective To explore the significance of CD64 index in differentiation of secondary infection and the disease activity in the patients with systemic lupus erythematosus（SLE）. Methods Eighty-seven SLE patients were divided into groups of A（with bacterial infection, 32 cases） and B （without bacterial infection, 55 cases）. Based on SLE disease activity index（SLE DAD, the patients in group B were assigned into subgroups of Bl（with active SLE, SLE DAIS8 points, 25 cases） and B2 （with stable SLE, SLE DAI 〈 8 points, 30 cases）. Thirty healthy volunteers were taken as control group（group C）. The mean fluorescence intensity of CD64 on the surfaces of neutrophils, monocytes and lymphoeytes was detected by flow cytometry, and CD64 index was calculated, relationship between CD64 index and infectious indexes and disease activity indexes was analyzed. Results CD64 index was significantly higher in group A than that in groups of B1 ,B2 and C（7. 90±3. 43 vs. 2. 44±0. 98,1.49 ±0.64 and 1. 45±0. 61） （P%0. 01）. CD64 index in group A was positively correlated with the levels of white blood cell, neutrophils, erythrocyte sedimentation rate, C-reactive protein and procalcitonin （r=0. 483, r=0. 535, r=0. 601, r=0. 676 and r=0. 724, P〈0. 01）, but was negatively correlated with SLE DAI, anti-nuclear antibody, anti-ds-DNA antibody, complement 3 （C3） or C4 （P〉0. 05 ）. There was no significant correlation between CD64 index and all indicators in group B1 （P〉0. 05）. Conclusion CD64 index can be used as an important indicator for differentiating the secondary infection from the disease activity in SLE patients.

关 键 词：CD64指数 系统性红斑狼疮 

分 类 号：R593[医药卫生—内科学]