丹酚酸组分磷脂复合物制备研究  

Study on preparation of salvianolic acid phospholipid compound

作　　者：陈小云[1,2] 张振海[2] 刘丹[2] 郁丹红[1,2] 孙娥[2] 贾晓斌[1,2] 

机构地区：[1]南京中医药大学,江苏南京210046 [2]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028

出　　处：《中国中药杂志》2014年第2期216-221,共6页China Journal of Chinese Materia Medica

基　　金：国家"十一五"科技支撑计划项目(2008BAI51B03);国家中医药管理局中药口服制剂释药系统重点研究室开放基金课题(2011NDDCM01002);江苏省中医药领军人才专项(2006)

摘　　要：制备丹酚酸组分磷脂复合物,以丹酚酸组分与大豆磷脂的复合率为指标,采用单因素试验和正交试验筛选其工艺参数,结果可得丹酚酸组分磷脂复合物制备的最佳条件为以四氢呋喃为反应溶剂,反应时间3 h,反应物质量浓度5 g·L-1,药物与磷脂的反应投料质量比1∶1.5,反应温度40℃。所制备的丹酚酸组分磷脂复合物在水和不同pH缓冲液中的油水分配系数得到较大提高,DSC,XRD,FTIR等物相分析结果表明丹酚酸组分以无定形状态存在于磷脂中。To prepare salvianolic acid phospholipid compound. With the compound of salvianolic acids and soybean phospho- lipid as the index, mono-factor experiment and orthogonal design experiment were conducted to screen its technical parameters. Ac- cording to the results, the optimal preparation conditions of salvianolic acid phospholipid compound were that THF were taken as the re- action solvent, the concentration time was 3 h, the reactant concentration was 5 g ~ L- i, the mass ratio of salvianolic acids and phos- pholipid was 1 ： 1.5, and the reaction temperature was 40 ~C. The oil/water partition coefficient of the prepared salvianolic acid phos- pholipid compound significant increased in water and buffers wifll different pH values. The results of phase analysis such as DSC, XRD and FTIR indicated that salvianolic acids existed in phospholipid in an amorphous state.

关 键 词：丹酚酸组分 磷脂复合物 油水分配系数 表征 

分 类 号：TQ461[化学工程—制药化工] R283[医药卫生—中药学]