涂层可降解与不可降解药物洗脱支架在冠状动脉疾病治疗中的对比研究  

Comparative study of using biodegradable polymer drug eluting stents and durable polymer drug eluting stents in the treatment of coronary artery disease

作　　者：李时乐[1] 徐延敏[1] 

机构地区：[1]天津医科大学第二医院心脏科,天津300211

出　　处：《天津医科大学学报》2014年第1期21-24,共4页Journal of Tianjin Medical University

摘　　要：目的:比较涂层可降解药物洗脱支架(Excel)与涂层不可降解药物洗脱支架(Partner)在冠状动脉疾病治疗中的近期疗效及安全性。方法:将1 315例接受药物洗脱支架治疗的冠心病患者纳入此回顾性对照研究,其中Excel组498例,Partner组817例.观察术后1年内两组患者主要不良心脏事件(MACE)及支架内血栓事件发生情况。结果:两组患者在基线资料、冠脉病变特征等方面均无统计学差异(P>0.05);两组患者平均置入支架直径[(2.97±0.39)mm vs(3.03±0.46)mm]及置入支架长度[(25.37±7.39)mm vs(24.57±7.11)mm]比较,差异均有统计学意义(P<0.05)。尽管Excel组患者平均置入支架直径较小且支架长度偏长,但随访结果显示两组患者1年内主要不良心脏事件及支架内血栓事件发生情况差异均无统计学意义(2.41%vs 2.69%,P>0.05;0.60%vs 0.86%,P>0.05)。结论:涂层可降解与不可降解药物洗脱支架在冠状动脉疾病治疗中的近期疗效及安全性相似。Objective： To compare the short-term effect and safety of biodegradable polymer drug eluting stents （Excel） and durable polymer drug eluting stents （Partner） in the treatment of coronary artery disease. Methods： A cohort of 1315 consecutive patients with coronary arterial disease who underwent drug eluting stents implantation was carried out .The patients were divided into Excel group （n=498） and Partner group （n=817）. The incidence of main adverse cardiac event （MACE） and stent thrombosis （ST） were followed up within one year. Results： Two groups were similar in main baseline clinical information and major angiography characteristics. While the stents of the Excel group had a smaller diameter [（2.97±0.39）mm vs （3.03±0.46）mm] and a longer length [（25.37±7.39）mm vs （24.57±7.11）mm] than the those of Partner group on average, the difference was statistically significant. During the period of follow-up, the incidence of MACE was 2.41% in Excel group and 2.69% in Partner group, with no significant difference （P〉0.05）; and the incidence of stent thrombosis was 0.60% in Excel group whereas 0.86% in Partner group, indicating no significant difference （P〉0.05）. Conclusion： The short-term effect and safety of biodegradable polymer drug eluting stents（Excel） and durable polymer drug eluting stents （Partner） in the treatment of coronary artery disease are similar.

关 键 词：冠状动脉疾病 药物洗脱支架 涂层可降解 对比研究 

分 类 号：R541.4[医药卫生—心血管疾病]