侵袭性肺部真菌感染患儿(1,3)-β-D葡聚糖检测的临床价值  

The clinical value of(1,3)-beta-D glucan detection in children with invasive pulmonary fungal infection

作　　者：赖源[1] 朱纯华[1] 刘娜[1] 叶志纯[1] 李梨平[1] 

机构地区：[1]湖南省儿童医院儿科研究所,湖南长沙410007

出　　处：《国际检验医学杂志》2014年第1期27-28,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨支气管肺泡灌洗液(BALF)及血浆(1,3)-β-D葡聚糖检测对侵袭性肺部真菌感染患儿诊断的临床价值。方法选择25例侵袭性肺部真菌感染(IPFI)患儿作为研究组,同时以同期28例单纯肺炎患儿及26例非感染患儿作为对照。收集所有患儿的支气管肺泡灌洗液进行(1,3)-β-D葡聚糖试验(G试验),并与其血浆G试验比较。结果研究组的BALF G试验检测值为(279.0±121.3)pg/mL,血浆G试验检测值为(98.5±32.6)pg/mL,均显著高于单纯肺炎组和非感染组(P<0.05),对照组的BALF G试验检测值显著高于血浆G试验检测值(P<0.05)。BALF标本G试验诊断IPFI的灵敏度和特异度均明显高于血浆G试验。结论 BALF G试验较血浆G试验在诊断侵袭性肺部真菌感染方面具有更早、更准确、更高的临床价值。Objective To discuss the clinical value of （1,3）-β-D glucan in bronchoalveolar lavage fluid （BALF） for the diagnosis of invasive pulmonary fungal infection （IPFI） in children. Methods 25 cases of IPFI children were collected as research group. 28 cases of simple pneumonia children and 26 cases of non-infective children were collected as control at the same time. （1,3）-β-D glu- can test（G test） in BALF and blood plasma was carried out and the results were compared. Results The value of BALF G test and blood plasma G test were （279.0 ± 121.3）pg/mL and（98.5 ±32.6）pg/mL in research group respectively and were both observably higher than that in simple pneumonia and non-infective group（P〈0.05）. The value of BALF G test was observably higher than that of blood plasma G test in research group（P〈0.05）. The sensitivity and specificity of BALF G test was observably higher than that of blood plasma G test for the diagnosis of IPFI. Conclusion The clinical value of BALF G test is earlier and more accurate, and has higher clinical value than blood plasma G for the diagnosis of IPFI.

关 键 词：肺疾病 真菌性 葡聚糖类 支气管肺泡灌洗液 血浆 

分 类 号：R725.1[医药卫生—儿科]