服用不同抗高血压药物后肾素-血管紧张素-醛固酮系统活性变化与血糖水平的关系  

Association between variety of renin-angiotensin-aldostetone system activity and glucose level after different anti-hypertensive medication

作　　者：李云[1] 杨鹏[1] 吴寿岭[2] 梁洁[2] 刘楠[1] 王砚飞[1] 任琦[1] 武英[1] 赵丹丹[1] 冯福民[1] 

机构地区：[1]河北联合大学公共卫生学院,河北省唐山市063000 [2]河北联合大学附属开滦医院心内科,河北省唐山市063000

出　　处：《实用医学杂志》2014年第1期58-60,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81000110);河北省高校百名优秀创新人才支持计划;河北省高等学校科学技术研究优秀青年基金项目(编号:YQ2013004)

摘　　要：目的:探讨服用不同抗高血压药物1年后肾素-血管紧张素-醛固酮系统(RAAS)活性变化与血糖水平变化间的关系。方法:368例高血压患者随机分为氢氯噻嗪组(119例)、螺内酯组(126例)和卡托普利组(123例),服用不同药物1年后分析RAAS活性变化与血糖水平变化之间的相关性。结果:服用不同抗高血压药物1年后,基线血糖水平(B=-0.200,P<0.001)、服药后肾素活性变化幅度(B=0.144,P=0.020)、血管紧张素Ⅱ变化幅度(B=0.004,P=0.039)与服药后血糖变化幅度相关。结论:服用不同抗高血压药物1年后,RAAS活性下降幅度与血糖水平下降幅度呈正相关。Objective To investigate the association between the variety of renin-angiotensin-aldostetone system （RAAS） activity and glucose level after different antihypertensive medication for one year. Methods A total of 368 hypertensive patients were divided into 3 groups and were respectively treated with different drugs. Results After one year treatment with different antihypertensive drugs, there were positive correlation between the glucose change and the changes of renin（B = 0.144,P = 0.02） and angiotensin II（B = 0.004,P = 0.039）, blood glucose levels at baseline （B = -0.200,P 〈 0.001） after the medication. Conclusion After one year of different anti- hypertensive medication, there is a positive correlation between RAAS activity change and glucose level change.

关 键 词：高血压 肾素-血管紧张素-醛固酮系统 血糖 抗高血压药物 

分 类 号：R544.1[医药卫生—心血管疾病]