蛹虫草子实体的药效学实验研究及毒性分析  

Pharmacodynamics research and toxicity analysis of cordyceps militaris

作　　者：柴惠霞[1] 王玲玲[1] 

机构地区：[1]河北师范大学校医院,河北石家庄050024

出　　处：《中国妇幼保健》2014年第3期446-448,共3页Maternal and Child Health Care of China

基　　金：河北省自然科学基金〔C2011205111〕资助

摘　　要：目的:探讨蛹虫草子实体对慢性盆腔炎的药效学作用。方法:通过二甲苯所致小鼠耳肿胀模型观察蛹虫草子实体的抗炎作用;小鼠醋酸扭体反应观察外周镇痛作用;测量抑菌圈直径评价体外抑菌作用;最大给药量试验观察毒性反应。结果:蛹虫草子实体可以缓解小鼠耳肿胀程度,延长扭体潜伏期,减少扭体次数,抑制大肠杆菌、金黄色葡萄球菌及链球菌生长,最大给药剂量下无明显毒性反应。结论:蛹虫草子实体对慢性盆腔炎具有良好的抗炎、镇痛、抑菌作用,且毒性很低。Objective： To detect pharmacodynamics effects of cordyceps on militarischronic pelvic inflammatory disease. Methods： Xylene - caused ear edema model of mouse was used, the model mice body torsion reaction of acetic acid peripheral analgesic action was detected, bacteriostatic ring diameter in vitro after adding the extraction of cordyceps militaris was assayed, the toxicity reaction after giving the different dosage of cordyceps militaris to mice was observed. Results： The extraction of cordyceps militaris could alleviate the symptom of mouse ear edema, prolong the body torsion period, decrease the times of twisting and inhibit the growth of Escherichia coli, Staphylococcus aureus and Streptococcus. At the permitted maximum dosage of the extraction of cordyceps militaris, no obvious toxic effects were found. Conclusion： Cordyceps militaris has an obvious effect on chronic pelvic inflammatory.

关 键 词：慢性盆腔炎 药效学实验 毒性实验 

分 类 号：R711.33[医药卫生—妇产科学]