新生儿缺氧缺血性脑病胰岛细胞分泌水平测定  

DETERMINATION ON SECRETING LEVED OF PANCREATIC ISLET CELLS IN NEWBORN INFANTS WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY.

作　　者：赵幽燕[1] 吴玲[1] 过国英[2] 

机构地区：[1]南京市儿童医院,210008 [2]南京军区总医院

出　　处：《新生儿科杂志》2000年第6期245-246,259,共3页The Journal of Neonatology

摘　　要：为了解新生儿缺氧缺血性脑病时胰岛细胞分泌水平的改变以及对机体的影响。应用放射免疫法检测了 40例缺氧缺血性脑病 (HIE)新生儿及 2 4例正常足月新生儿作对照血中胰岛素、胰高糖素、血糖在急性期及恢复期各测一次。结果表明HIE患儿急性期胰岛素明显高于对照组 (P<0 .0 1 ) ,胰高糖素降低 ,且恢复较慢 ,血糖亦降低。提示 HIE患儿低血糖与胰岛细胞激素分泌紊乱有关 ,对 HIE患儿应密切监测血糖变化 ,及早发现和尽快纠正低血糖 。To know the changing of pancreatic islet cell's secreting lever in newborn infants with Hypoxic ischemic Encephalopathy and the effects to the organism. Insulin, glucagon and blood sugar were neasured in 40 newborn infants with HIE and 24 normal infants (control)by radioimmunoassar, each in acute stage and convalescent stage. The results showed: the insulin were significantly higher in acute stage of HIE group than in the control group (P<0.01), the glucagon were decresed and recovered slowly, the blood suger also were decresed. It suggests that hypoglycemia in newborn infants with HIE were associated with the disturbance of parcreatic islet cell's secreting hormone. So we should monitor closely the changing of the blood suger and discover promptly to correct hypoglycemia as soon as possible, the avoid to aggravate brain injury further. (Original article on page 245)

关 键 词：缺氧缺血性脑病 新生儿 胰岛素 胰高糖素 

分 类 号：R722.12[医药卫生—儿科]