孕妇血浆次黄嘌呤水平预测胎儿宫内窘迫缺氧程度的研究  

A STUDY ON THE MATERNAL BLOOD PLASMA HYPOXANTHINE IN PERINATAL ASPHYXIA

作　　者：刘俐[1] 曹晖[2] 苏祖佑[1] 刘惠喜[1] 屈新中 党少农 牛映斗[2] 王哲训 

机构地区：[1]西安医科大学第一临床医学院妇产科医院新生儿科,710061 [2]西安医科大学第一临床医学院妇产科医院,710061

出　　处：《新生儿科杂志》2000年第6期251-253,共3页The Journal of Neonatology

基　　金：美赞臣科研基金;西安医科大学第一临床医学院院科研基金

摘　　要：探讨孕妇血浆次黄嘌呤对胎儿、新生儿缺氧状况的预测可能及价值 ,应用方法是采用改良酶学法检测 40例产前诊断为胎儿宫内窘迫的孕妇及所生新生儿血浆次黄嘌呤浓度 ,以同期 40例产前无胎儿宫内缺氧的孕妇及新生儿为对照 ,同时进行当前常用缺氧指标的评定及临床观察。结果显示 :缺氧组孕妇及其新生儿脐血浆Hx明显高于对照组 (P<0 .0 0 1 )。孕妇血浆 Hx与新生儿脐血浆 Hx呈明显正相关 (r=0 .6 2 6 ,P<0 .0 1 )。以对照组 x± t0 .1 0 s为参照 ,孕母及其新生儿血浆 Hx与常用围产期缺氧 8项指标比较诊断指数分别为 :0 .7、0 .775明显高于其它指标。因此 ,孕妇血浆 Hx可做为围产期缺氧早期监测、防治有很大临床价值的指标 。Investigate the significance of plasma hyposanthine concentration in pregnant women whose babies sufer from uterin distress and some newbrn bales with asphyisa. Using methods of delermuntio levels of plasma hypoxanthine of 40 matennal arteral and their neontal cord blood samples were assged by means of modified enzymologic method, Tht blood gas nalysis、apgar score and other judging indicatiors were also done at the sametime 40 normal pregnant women and their babes burned in the same period were used as contral group. Results showel that the hypoxanthine of maternal and neonatal plasma of hypoxia group were significantly higher than those in contral group (P<0.001). And the maternal levels of plasma hypoxanthine weve significantly positive correlated with neonatal cord plasma (r=0.626, P<0.01). Used the levels of ±t 0.10 s the control group as the upper limits, the sensitivities of maternal and neonatal plasma hypoxanthine、blood gas analysis、Apgar score、fetal heart rate、fetal heant electronic monitoring 、amniotic fluid pollution and fetal movement、placenta、umbilical cord abnomal for judging perinatal hypoxia (Youden's Index) [WT5,5”BZ]were 0 7、0 775、0 25、0 575 、 625、0 575、0 1、0 and 0.275 respectively. Therebore the maternal plasma hypoxanthmie was a usefel indcator for early prediction of perinatal asphyxia. (Original article on page 251)

关 键 词：缺氧 预测 次黄嘌呤 胎儿 新生儿 

分 类 号：R446.11[医药卫生—诊断学]