甲胺鸢尾素对冠脉结扎致急性心肌缺血大鼠心功能的影响  

Protective Effect of Methylamine Irisolidone on Cardiac Function in Rats with Acute Myocardial Infarction

作　　者：牟艳玲[1] 王福文[1] 张强[1] 王燕[1] 

机构地区：[1]山东省医学科学院药物研究所,山东省罕少见病重点实验室,济南250062

出　　处：《中国药学杂志》2014年第2期126-128,共3页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(30701022)

摘　　要：目的观察新化合物甲胺鸢尾素对冠脉结扎致急性心肌缺血大鼠心功能的影响。方法雄性Wistar大鼠60只,采用冠状动脉结扎的方法制备急性心肌缺血损伤模型,模型成功大鼠随机分为6组,即正常对照组、模型组、甲胺鸢尾素不同剂量组(200、100、50 mg·kg-1),阳性对照葛根素注射液(200 mg·kg-1)组,腹腔注射连续给药30 d。检测大鼠心功能相关指标,即心率(HR)、收缩压(SBP)、舒张压(DBP)、左心室收缩压(LVSP),左室收缩压最大变化速率(±dp/dt max)的变化情况,并取心室肌标本进行HE染色观察心肌病理改变。结果甲胺鸢尾素腹腔注射给药30 d后,200、100 mg·kg-1剂量组与模型组比较,大鼠心率减慢,收缩压、舒张压明显升高;左心室内压明显升高,左室内压力最大上升速率明显升高,最大下降速率亦显著升高(P<0.01),心肌病理改变明显减轻。结论甲胺鸢尾素具有改善急性心肌缺血大鼠心功能的作用,其作用机制可能与减慢心率、延长舒张期,从而使心内膜血供增加有关。OBJECTIVE To observe the effect of a new compound methylamine irisolidone on cardiac function in rats with experi- ment myocardial infarction. METHODS The male Wistar rats were randomly divided into 6 groups： control group, ischemia model group, methylamine irisolidone preconditioning group, pretreated with different dosages of methylamine irisolidone （200,100,50 mg· kg-L, respectiveIy） and 200 mg· kg-1 puerain （positive control）. Coronary artery ligation was used to induce the acute myocardial is- chemia model. After 30 d administration of methylamine irisolidone, the heart function parameters, including heart rate （HR）, systolic blood pressure （SBP）, diastolic blood pressure（DBP） ,left ventricular systolic pressure（LVSP） ,maximal velocity of increase and de- crease of left ventriclar pressure （ dp/dtmax ）, were analyzed and myocardial histology was analyzed by hematoxylin-eosin staining. RE- SULTS Compared with model group, methylamine irisolidone could improve the heart function of rats in AMI injury, increased the systolic pressure and diastolic pressure, decreased the heart rate（ P 〈 0. 01 ） . The myocardial uhrastructure injury was alleviate. CONCLUSION Methylamine irisolidone had cardioprotective effects on acute myocardial ischemia. The mechanism may be related to slow down heart rate, prolong diastolic, so that an increase in the endocardial blood supply.

关 键 词：甲胺鸢尾素 心肌缺血 心功能 大鼠 

分 类 号：R965[医药卫生—药理学]