2007-2011年鲍氏不动杆菌临床分布与耐药性变迁分析  

Clinical distribution of Acinetobacter baumannii and change of drug resistance from 2007 to 2011

作　　者：白丽红 赵华[1] 谢正福[1] 闫萍[1] 

机构地区：[1]广西医科大学第一附属医院老年呼吸内科,广西南宁530021

出　　处：《中华医院感染学杂志》2014年第2期295-297,共3页Chinese Journal of Nosocomiology

基　　金：广西科学基金资助项目(桂科基0575075);广西卫生厅自筹科研基金资助项目(桂卫Z2007049、Z2008154)

摘　　要：目的了解鲍氏不动杆菌感染及耐药性变迁,为临床合理应用抗菌药物提供理论依据,预防及减少医院感染的发生。方法回顾性分析2007年1月-2011年12月医院住院患者鲍氏不动杆菌标本的来源、科室分布及药敏试验结果,用K-B法判断菌株耐药性。结果 2007-2011年各类标本中共分离出鲍氏不动杆菌2 762株,标本来源主要为痰,共1 866株,占67.56%;临床分布以ICU为主,2007-2011年的构成比例均较高,约占50.0%;鲍氏不动杆菌对13种常用抗菌药物的耐药性呈逐年上升趋势,2007年头孢哌酮/舒巴坦、美罗培南、亚胺培南耐药率较低,分别为1.15%、8.02%、4.01%,至2011年其耐药率分别升至19.54%、75.69%、76.85%;共分离多药耐药鲍氏不动杆菌(MDRAB)1 382株,检出率为50.04%,泛耐药鲍氏不动杆菌(PDRAB)1 208株,检出率为43.74%。结论鲍氏不动杆菌在临床科室的检出率及耐药率呈逐年上升的趋势,多药耐药及泛耐药现象明显。OBJECTIVE To understand the infection and drug resistance change of Acinetobacter baumannii so as to provide theoretical basis for rational use of antibiotics and prevent and reduce the incidence of nosocomial infec- tions. METHODS A retrospective analysis was performed for the sources, the distribution and results of the drug susceptibility testing of A. baumannii clinical specimens obtained from Jan. 2007 to Dec. 2011 ; the drug resistance was determined with K-B method. RESULTS A total of 2 762 strains of A. baumannii were isolated from 2007to 2011 in our hospital. The main specimens were sputum（1 866 strains ）, the constituent ratio was 67. 56% ; these strains mainly distributed in ICU, with high constituent ratio every year. The drug resistance to 13 kinds of com- mon antibiotics increased as the time passed. The drug resistance to cefperazone-sulbactam, meropenem, and imi- penem were respectively 1.15%, 8.02%, 4.01% in 2007 ,and 19.54%, 75.69%, 76.85% in 2011. Totally 1 382 strains of multidrug-resistant A. baumannii （MDRAB） have been isolated with the detection rate of 50.04%, and 1 208 strains of pandrug-resistant A. baurnannii （PDRAB） have been isolated with the detection rate of 43.74%. CONCLUSION The isolation rate and the drug resistance rate of the A. baumannii strains increase year by year in the clinical departments, and the strains show high multidrug-resistance and pandrug-resistance.

关 键 词：鲍氏不动杆菌 临床分布 耐药性 

分 类 号：R378[医药卫生—病原生物学]