甘肃省2012年甲型肝炎灭活疫苗群体性预防接种疑似预防接种异常反应分析  

Analysis on the Adverse Events Following Immunization after Mass Vaccination Campaign of Inactivated Hepatitis A Vaccine in Gansu Province in 2012

作　　者：梁雪枫[1] 安婧[1] 李凤琴[1] 唐宇[1] 金娜[1] 张晓曙[1] 

机构地区：[1]甘肃省疾病预防控制中心,兰州730000

出　　处：《中国疫苗和免疫》2013年第6期506-508,500,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解甘肃省2012年甲型肝炎(甲肝)灭活疫苗(Hepatitis A Vaccine,Inactivated;HepA-I)群体性预防接种中,疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的发生特征,评价HepA-I的安全性。方法采用描述性流行病学方法,对AEFI监测系统中的相关数据进行统计分析。结果甘肃省2012年接种HepA-I 760 451剂,发生AEFI 95例,AEFI报告发生率124.92/100万剂。其中一般反应90例,报告发生率118.35/100万剂,异常反应3例,报告发生率3.94/100万剂,心因性反应2例,报告发生率2.63/100万剂。结论群体性接种HepA-I的AEFI发生率低,HepA-I具有良好的安全性。Objective To analyze the characteristics and the patterns of adverse events following immunization （AEFI） after mass vaccination campaign of inactivated hepatitis A vaccine （HepA-I） in Gansu province in 2012 and evaluate the safety of HepA-I. Methods The data from AEFI surveillance system were analyzed by descriptive epidemiology. Results 760,451 doses of HepA-I were inoculated in mass vaccination campaign in Gansu province in 2012, and 95 AEFI cases were reported, the incidence was 124.92 per million doses. Of the reported cases , 90 cases were verified as minor vaccine reaction, reporting rate was 118.35 per million doses, 3 cases were verified as rare, serious reactions, reporting rate was 3.94 per million doses. 2 cases were verified as psychogenic reaction, reporting rate was 2.63 per million doses. Conclusion It shows a relatively low incidence rate of AEFI with HepA-I in the large scale inoculation and it was safe.

关 键 词：甲型肝炎灭活疫苗 群体性预防接种 疑似预防接种异常反应 监测 

分 类 号：R186[医药卫生—流行病学] R512.61[医药卫生—公共卫生与预防医学]