血吸虫尾蚴侵染分子机制研究进展  

Progress in researches of molecular mechanism of schistosome cercariae infection

作　　者：杜晓峰[1] 鞠川[2] 胡薇[1,2] 

机构地区：[1]复旦大学生命科学学院微生物与微生物工程系,上海200433 [2]中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾,血吸虫和丝虫病合作中心

出　　处：《中国血吸虫病防治杂志》2013年第6期664-667,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家自然科学基金(81271867)

摘　　要：尾蚴穿透宿主皮肤是血吸虫成功感染终宿主的第一步。尾蚴钻腺分泌的蛋白酶在穿透宿主皮肤过程中发挥了重要作用。目前对于血吸虫感染分子机制的研究主要集中在包括丝氨酸蛋白酶和半胱氨酸蛋白酶在内的尾蚴分泌蛋白酶上。已有研究表明,曼氏血吸虫主要靠尾蚴分泌的弹性蛋白酶穿透宿主皮肤,日本血吸虫则主要利用组织蛋白酶B2侵入宿主体内。尾蚴入侵分子机制的阐明有助于新型血吸虫病疫苗的研制和药物靶点的发现。Schistosome cercariae must penetrate skin as an initial step to successfully infect the final host. Proteolytic enzymes secreted from the acetabular glands of cercariae contribute significantly to the invasion process. Nowadays,the researches of molecular mechanism of schistosome infection mainly focus on the cercarial secretions including serine protease and cysteine protease. Previous researches already showed that Schistosoma mansoni penetrates the skin mainly depend on cercarial elastease secreted by cercariae while Schistosoma japonicum penetrates the skin chiefly by cathepsin B2. The illustration of molecular mechanism of schistosome cecariae infection will accelerate the identification of novel vaccines and drug targets.

关 键 词：血吸虫 尾蚴 感染机制 蛋白酶 

分 类 号：R383.24[医药卫生—医学寄生虫学]