强心饮对心衰病模型大鼠心功能及心肌肥厚影响的实验研究  

Experimental Study on the Effect of Qiangxin Decoction on the Cardiac Function and Cardiac Hypertrophy in Rats with Heart Failure

作　　者：郑晓丹[1] 姜卫东[1] 高想[1] 倪卫兵[1] 陶志强[1] 蔡娟[1] 任秀梅[2] 杨英俏 高俊杰[4] 

机构地区：[1]江苏省南通市中医院,江苏南通226001 [2]南通大学附属医院,江苏南通226001 [3]辽宁省锦州市中医医院,辽宁锦州121014 [4]上海中医药大学附属曙光医院,上海201203

出　　处：《云南中医学院学报》2013年第6期15-18,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：江苏省南通市社会事业科技创新与示范项目(NO:HS12952)

摘　　要：目的观察强心饮对阿霉素诱导的心肌肥厚大鼠相关调控细胞生长与增殖蛋白表达的变化,以探讨强心饮对心肌肥厚潜在的作用机制。方法 40只SD大鼠随机分为5组:模型组、正常组、雷帕霉素组、强心饮大剂量组、强心饮小剂量组。采取腹腔注射阿霉素复制大鼠心肌肥厚模型,观察大鼠心肌形态学、血流动力学、心衰指标及调控心肌肥厚相关蛋白表达的变化。结果与模型组比较,强心饮治疗组明显改善心肌肥厚大鼠心脏结构及功能,降低心肌组织BNP含量,抑制调控细胞生长蛋白mTOR及p70S6K的磷酸化(P<0.01或P<0.05)。结论强心饮能改善心肌肥厚大鼠心功能及抑制心肌肥厚,其机制可能调控p-mTOR及p-p70S6K的表达有关。Objective To observe the effects of Qiangxin decoction on protein expression of regulation cell growth and proliferation in Rats with Adriamycin （ADR）-induced cardiac hypertrophy,and to investigate potential molecular mechanisms of cardiac hypertrophy. Methods Forty Sprague Dawley rats were randomly divided as follows：ADR group,normal control group, rapamycin treatment group,high and low dosage Qiangxin decoction groups. The morphology,hemodynamic,brain natriuretic peptide, and relative protein expression of cardiac hypertrophy were observed. Results Compared with ADR group, Qiangxin decoction treatment significantly inhibited the extent of the cardiac hypertrophy,improved cardiac function,while the expression level of phosphorylated mTOR （p-mTOR）and phosphorylated p70S6K （p- p70S6K）significantly reduced. Conclusion The present study demonstrated that Qiangxin decoction significantly relieve the myocardial hypertrophy and improve the cardiac function,The protective effect of the derivatives could be due to the inhibition of the activities of p-mTOR and p-p70S6K.

关 键 词：强心饮 心肌肥厚 P-MTOR p-p70S6K 

分 类 号：R285.6[医药卫生—中药学]