壳聚糖基双氯芬酸钠微丸的制备及体外缓释性能研究  

Preparation and Sustained-release Properties in Vitro of Chitosan-based Diclofenac Sodium Micropellets

作　　者：李国祥[1,2] 杨磊[2] 卢代婵 施新丹 蔡明月[2] 邵宇[2] 

机构地区：[1]生物资源保护与利用湖北省重点实验室(湖北民族学院),湖北恩施445000 [2]湖北民族学院化学与环境工程学院,湖北恩施445000

出　　处：《湖北民族学院学报（自然科学版）》2013年第4期411-413,435,共4页Journal of Hubei Minzu University(Natural Science Edition)

基　　金：湖北省教育厅自然科学基金项目(Q20122907);湖北民族学院博士基金项目(MY2011B011);生物资源保护与利用湖北省重点实验室开放基金项目(PKLHB1112)

摘　　要：以壳聚糖为载体,双氯芬酸钠为模型药物,采用溶胶-凝胶法成功制备了双氯芬酸钠微丸.考察了微丸的形貌,并模拟人体胃肠道微环境探讨了凝固液、交联剂以及不同pH条件下微丸缓释性能.结果表明:载药微丸呈规整的圆形,直径约2 mm,微丸释药特性与其凝固液、交联剂浓度和释药体系均有关.随交联剂浓度的上升,微丸的释药率下降,微丸在酸性和中性介质中缓释性能较好,累积释放量均超过600!g.Drug loaded pellets were successfully prepared from chitosan and diclofenac sodium by sol-gel methods. The morphology of pellets was investigated. Sustained release properties of pellets were studied in different conditions by simulating gastrointestinal tract environment, including the concentration of cross -/inking agent, cross-linking time, solidified liquid concentration and different pH. The results show that the pellets are perfectly circular, and the diameter is about 2 ram. All pellets have good sustained-release properties. Moreover, the cumulative release amount of pellets is more than 600 I-tg in acidic and neutral media.

关 键 词：双氯芬酸钠 壳聚糖 缓释制剂 

分 类 号：O657.7[理学—分析化学]