EMIT与FPIA法测定肾移植术后患者体内环孢素A血药浓度结果比较  

Comparison of the result of the two methods to determine the concentration of cyclosporine A in patients after renal transplantation

作　　者：廉江平[1] 李小川[1] 张鹏[1] 方志远[1] 

机构地区：[1]陕西省人民医院药剂科,陕西西安710068

出　　处：《安徽医药》2013年第12期2039-2041,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的比较酶扩大免疫法(EMIT)和荧光偏振免疫法(FPIA)监测环孢素A(CsA)血药浓度的相关性。方法收集肾移植患者服药后达稳态的谷浓度血样,分别用EMIT法和FPIA法进行测定,考察两种方法测定结果的相关程度。结果两种方法测定结果高度相关,差异有显著性。结论 EMIT法和FPIA法测定CsA血药浓度结果差异具有统计学意义,在CsA治疗药物监测中应予以关注并作相应调整。Objective To compare the results of enzyme-multiplied immunoassay technique（EMIT） and fluorescence polarization immu- noassay（FPIA） in monitoring cyclosporine A （CsA） in patients after renal transplantation. Methods Plasma samples were collected from renal transplantation patients. Both EMIT and FPIA were employed to determine the concentration of CsA. The results of two methods were analyzed for their correlation. Results The two methods had good correlations in statistics. Conclusion We should pay attention to the difference of CsA monitoring by EMIT and FPIA.

关 键 词：酶扩大免疫法 荧光偏振免疫法 环孢菌素A 肾脏移植 

分 类 号：R96[医药卫生—药理学]