布地奈德联合福莫特罗雾化吸入治疗慢性阻塞性肺疾病的临床疗效观察  

Effect of Aerosol Inhalation of Budesonide Combined with Formoterol in the Treatment of COPD

作　　者：赵焕[1] 石寒冰[1] 毕红霞[1] 

机构地区：[1]齐齐哈尔医学院附属第三医院呼吸科,黑龙江省齐齐哈尔市161005

出　　处：《中国全科医学》2013年第35期4219-4221,共3页Chinese General Practice

摘　　要：目的观察糖皮质激素布地奈德联合β2-受体激动剂福莫特罗雾化吸入对慢性阻塞性肺疾病(COPD)患者症状、肺功能、炎性递质的影响,探讨本方案的临床疗效。方法选取2008年1月—2011年3月我院收治的96例COPD患者,按随机数字表分为对照组(48例)和观察组(48例)。对照组雾化吸入布地奈德,观察组在对照组治疗的基础上雾化吸入福莫特罗,两组均治疗3个月。比较两组患者治疗前及治疗后的肺功能〔1 s用力呼吸容积(FEV1)、用力肺活量(FVC)、FEV1占预计值的百分比(FEV1%)〕、动脉血氧分压(PaO2)、痰液炎细胞计数。结果 (1)治疗前两组患者FEV1、FEV1/FVC、FEV1%、PaO2及痰液炎细胞计数、中性粒细胞分数比较,差异均无统计学意义(P>0.05);治疗后两组患者FEV1、FEV1/FVC、FEV1%、PaO2较治疗前升高,而痰液炎细胞计数及中性粒细胞分数则较治疗前降低(P<0.05);且治疗后观察组患者肺功能各指标、PaO2较对照组升高,痰液炎细胞计数、中性粒细胞分数较对照组降低(P<0.01)。(2)治疗后对照组显效6例,有效31例,无效11例;观察组显效24例,有效21例,无效3例。两组患者临床疗效比较,差异有统计学意义(u=4.583,P<0.01)。(3)治疗中对照组1例出现恶心(2.1%),观察组3例(6.2%)出现口干及咽喉部不适。两组患者不良反应发生率比较,差异无统计学意义(χ2=1.054,P>0.05)。结论布地奈德联合福莫特罗雾化吸入治疗COPD临床疗效确切,能有效缓解症状、体征及炎性反应,恢复患者肺功能,且安全性好。Objective To observe the effect of aerosol inhalation of budesonide combined with formoterol in the treat- menton symptoms, lung function and inflammatory mediators of COPD and to explore the clinical value of this program. Methods 96 COPD patients admitted to our hospital from January 2008 to March 2011 were randomly divided into control group （48 ca- ses） and observation group （48 cases） . The control group was given aerosol inhalation of budesonide, while the observation group was given aerosol inhalation of both budesonide and formoterol. The two groups were both treated for three months. Lung functions of the two groups were compared between the two groups before and after treatment, including FEV1, FVC, FEV1 % , PaO2 and sputum examination. Results （1） FEVI, FEV1/FVC, FEV1 %, PaO2, sputum examination and neutrophil of the two groups showed no statistically significant difference before treatment （ P 〉 0.05 ） , but showed statistically significantly differ- ences after treatment, with FEV1, FEVJFVC, FEV1 % and PaO2 increasing and sputum examination and neutrophil decreasing （ P 〈 0. 05） . Besides, the indicators of lung function and PaO2 of observation group were significantly increased after treatment, while sputum inflammatory cells count and neutrophils scores were significantly decreased compared with control group （P 〈 0. 01 ） . （2） After treatment, in the control group, 6 cases were significantly improved, 31 cases were improved and 11 cases were invalid; In observation group, 24 cases were significantly improved, 21 cases were improved and 3 cases were invalid. The efficacy between the two groups showed statistically significant difference （ u = 4. 583, P 〈 0. 01 ） . （3） During treatment, one case in control group showed nausea （2. 1% ）, three cases in observation group had thirsty and throat discomfort （6. 2% ） . The rate of adverse effect between the two groups showed no statistically significant difference （ X2 = 1. 054, P 〉 0. 05） . Conclu

关 键 词：糖皮质激素类 肾上腺素能Β激动剂 布地奈德 福莫特罗 肺疾病 慢性阻塞性 治疗结果 

分 类 号：R563[医药卫生—呼吸系统]