脑络欣通治疗脑梗死恢复期气虚血瘀证的临床研究  

Clinical Observation on Naoluo Xintong Decoction for Treatment of Convalescent Cerebral Infarction Patients with Qi Deficiency and Blood Stasis Syndrome

作　　者：杨文明[1,2] 李祥 王键[3,4] 汪瀚 王晓旸 汪美霞 韩辉 董婷 何望生 

机构地区：[1]安徽中医药大学第一附属医院 [2]安徽省中医药科学院中医脑病防治研究所 [3]安徽中医药大学 [4]安徽省中医药科学院

出　　处：《中西医结合心脑血管病杂志》2013年第12期1424-1426,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家科技部支撑计划项目资金(No.2012BAI26B02);安徽省科技攻关基金项目(No.11010402167);康缘中医药科技创新基金项目(No.KYCX201010)

摘　　要：目的评价脑络欣通治疗脑梗死恢复期气虚血瘀证的临床疗效,观察脑络欣通对梗死后神经功能缺损程度和日常生活能力、中医证候积分及凝血功能变化的影响。方法将符合纳入标准的90例脑梗死恢复期气虚血瘀证患者随机分为脑络欣通组、通心络组、对照组,对照组给予常规治疗,通心络组在常规治疗基础上给予通心络胶囊,脑络欣通组在常规治疗基础上加用脑络欣通。观察治疗前、治疗后14d、治疗后28d三个不同时点的神经功能缺损程度评分、日常生活活动能力评分、中医证候积分值、凝血功能等指标变化。结果脑络欣通治疗脑梗死恢复期气虚血瘀证28d的总有效率为93.3%,优于通心络组和对照组(P<0.05或P<0.01),同时脑络欣通能改善病人的神经功能缺损程度、提高病人日常生活活动能力,明显降低中医证候积分值,改善凝血相关指标。结论脑络欣通对脑梗死恢复期气虚血瘀证患者有较好的治疗作用,其临床疗效优于通心络组。Objective To evaluate clinical effect of Naoluo Xintong decoction（NXD） for treatment of convalescent cerebral infarc- tion patients with qi deficiency and blood stasis syndrome, and to observe the effect of NXD on the indexes of score of neurological deficits and activities of daily living, traditional Chinese medicine （TCM） syndrome and coagulation function in cerebral infarction. Methods Ninc-ty patients with convalescent cerebral infarction and qi deficiency and blood stasis syndrome were randomly divided into three groups including NXD group, Tongxinluo capsule（TXL） group and control group. The conventional symptomatic treatment was given in control group, TXL plus conventional symptomatic treatment was given in TXL group, NXI） plus conventional symptom atic treatment were applied in NXD g group. The indexes of score of neurological defMts and activities of daily living, TCM syndrome ＂rod coagulation function in cerebral infarction were observed on the day of admission, 14 days and 28 days after the treatment. Results The total effective rate of NXD group trealing the cerebral infarction with Qi deficiency and blood stasis on day 98 after the treatment reached 93.30%, which was better than that of TXL group and control group,respectively there were significant differences between the three groups（P〈0.05 or P〈0.01）. Meanwhile. the score of neurological deficits of patients with cerebral infarction significantly was improved, the activities of daily living enhanced, the score of TCM syndrome reduced, and coagulation function improved in NXD group. Conclusion NXI） has obviously curative effect on patients with convalescent cerebral infarction and qi deficien- cy and blood stasis syndoroe. The clinical efficacy of NXD is better than that of TXI,, thereby NXD is worthy promoting the application.

关 键 词：脑梗死 气虚血瘀 脑络欣通 

分 类 号：R277.7[医药卫生—中医学]