A型肉毒毒素额部除皱后引起皮脂分泌改变的实验研究  

The Effect of Frontal Rhytidectomy by BTX-A Injection on Sebum Secretion

作　　者：闵沛如[1] 喜雯婧 苏薇洁[1] 冯少清[1] Aurelia Trisliana 濮哲铭[1] 张艳[1] 章一新[1] Lucrezia Pacchioni 

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,上海市200011 [2]Department of Plastic and Reconstructive Surgery, Azienda Ospedaliero Universitaria Policlinico Di Modena

出　　处：《组织工程与重建外科杂志》2013年第6期338-341,共4页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：目的：观察比较两种不同注射剂量的A型肉毒毒素（BTX-A）行额部注射除皱术后，引起局部皮脂分泌改变的情况，并研究其剂量和功效之间的关联。方法20例额部皱纹患者（中度至重度）随机分为注射总量10 U或20 U的两个治疗组。注射药物为宝妥适（BOTOX, BOTOX Cosmetic；Allergan, Irvine, CA），使用肌肉内注射标准五点法。评价注射后2周、4周、8周、16周患者额部注射区域（注射点外围半径0.5 cm区域、注射点外围半径0.6～1.5 cm环形区域、注射点外围半径1.6～2.5 cm环形区域）皮肤油脂分泌水平。结果两种不同剂量注射2周、4周、8周后额部注射点外围半径0.5 cm区域平均皮脂分泌水平较注射前显著下降（P＜0.05），注射16周后注射点外围半径0.5 cm区域平均油脂分泌水平于注射前相比没有显著差异。注射2周、4周、8周、16周后，注射点外围半径1.6～2.5 cm环形区域皮肤的平均油脂分泌水平显著高于注射前平均皮肤油脂分泌水平（P＜0.05），注射点外围半径1.6～2.5 cm环形区域皮肤的平均油脂分泌水平与注射前水平相比没有显著的统计学差异。结论10 U及20 U肌肉内BTX-A注射2周、4周及8周后，能显著减少注射点外围半径0.5 cm区域的皮脂分泌，并引起注射点外围半径1.6～2.5 cm环形区域皮肤的皮脂分泌增高。Objective To compare the efficacy of frontal rhytidectomy by different dosage of botulinum toxin type A on sebum secretion, and to investigate the correlation between the dosage and clinical efficacy. Methods Twenty volunteers with forehead ryhtides （moderate to severe） were received frontal rhytidectomy by BTX-A （BOTOX） intramuscular injection which was administered to 5 injective sites, and randomly divided into 2 groups according to different dosage （group 1：10 U;group 2：20 U）. Baseline and post-treatment （2, 4, 6, 8 weeks after injection） sebum production （the region 0.5 cm far around injection point, the region 0.6-1.5 cm far around injection point, the region 1.6-2.5 cm far around injection point） were measured. Results Significant reduction of sebum secretion was showed on the region 0.5 cm far around injection point after BTX-A injection for 2, 4, 8 weeks （P〈0.05） and no obvious change of sebum secretion was showed after BTX-A injection for 16 weeks （P〉0.05）. No significant difference was observed between the two groups. The sebum secretion of the region 1.6-2.5 cm far around injection point was increased after BTX-A injection for 2, 4, 8, 16 weeks （ P〈0.05）. Conclusion Intramuscular injection of BTX-A could reduce the sebum secretion of the region 0.5 cm far around the injection point and lead to the compensatory increase of sebum secretion on the region 1.6-2.5 cm far around injection point.

关 键 词：A型肉毒毒素 皮脂分泌 额部除皱术 

分 类 号：R622[医药卫生—整形外科]