中青年颈动脉粥样硬化斑块形成患者中医证型与血浆髓过氧化物酶、颈动脉斑块类型的关系  

The relationship among TCM syndrome classification,MPO and the type of carotid plaque in young and middle-aged patients with CAS plaque

作　　者：胡玉英[1] 刘泰[1] 胡跃强[1] 张青萍[1] 刘雪玲[1] 陈薇[1] 陈兴华[1] 

机构地区：[1]广西中医药大学第一附属医院脑病科,南宁530023

出　　处：《重庆医学》2014年第1期33-34,38,共3页Chongqing medicine

基　　金：广西壮族自治区卫生厅重点科研课题(2010091)

摘　　要：目的研究中青年颈动脉粥样硬化(CAS)斑块形成患者不同中医证型与血浆髓过氧化物酶(MPO)水平、颈动脉斑块类型之间的关系。方法对120例中青年CAS斑块形成患者进行中医辨证诊断,同时用ELISA方法测定其血浆MPO含量,颈动脉彩色多普勒超声检测颈动脉斑块类型,比较痰浊内阻证、血瘀证、精髓亏虚证及气虚证患者血浆MPO水平、不同斑块类型扁平斑、软斑、硬斑及复合斑块的变化。结果中青年各型CAS斑块形成患者血浆MPO水平均较健康对照组显著增高(P<0.05),其中痰浊内阻证、血瘀证患者血浆MPO水平、颈动脉软斑及复合斑块检出例数及检出率均较精髓亏虚证、气虚证患者显著增高(P<0.01)。结论中青年CAS患者血浆MPO水平可以在一定程度上反映患者CAS的程度及斑块的稳定性,其中痰浊内阻证、血瘀证患者血浆MPO水平、颈动脉软斑及复合斑块的变化具有一定特异性,为CAS的中医辨证分型提供了客观依据,同时也为CAS的早期发现及防治提供理论和实验依据。Objective To investigate the relationship among TCM syndrome classification ,M PO and the type of carotid plaque in young and middle-aged patients with CAS plaque .Methods To diagnose syndrome differentiation of TCM of 120 cases of young and middle-aged patients with CAS plaque and determine the level of plasma MPO with ELISA ;use Carotid Artery Doppler ultra-sound to detect the patterns of Carotid Artery plaque .Then compare the plasma MPO level in different patients with different syn-dromes of phlegm turbid retention syndrome ,blood stasis ,energy deficiency syndrome ,and deficiency of Qi ,and the changes in vari-ous types of plaque of flat plaque ,soft plaque ,hard plaque and mixed plaque .Results The MPO level of young and middle-aged pa-tients with CAS plaque increased significantly as compared with health controls （P〈0 .05） .Both the numbers and the ratio of the plasma MPO level ,cases of cervical artery soft plaque and mixed plaque detected in patients with phlegm turbid retention syndrome and blood stasis syndrome increased significantly compared to the patients with energy deficiency syndrome and deficiency of Qi syndrome （P〈0 .01） .Conclusion Plasma MPO level of young and middle-aged patients with CAS may reflect the degree of CAS and the stability of plaque to a certian extent .There are some specific effect about plasma MPO level and the changes of carotid soft plaque and mixed plaque in patients with phlegm turbid retention syndrome and blood stasis .It provides objective basis for syn-drome differentiation of TCM and provides the theoretic and experimental basis for early diagnose and treatment of CAS .

关 键 词：颈动脉粥样硬化 髓过氧化物酶 中青年 中医证型 

分 类 号：R543.4[医药卫生—心血管疾病]