四君子汤中用生晒参或红参对脾气虚证模型大鼠的影响  

Effects of Sun-dried Ginseng and Red Ginseng in Sijunzi Decoction on Spleen-qi Deficiency Model Rats

作　　者：赵远[1,2] 孙娜[1,2] 景海漪[1,2] 张凡[1,2] 贾天柱[1,2] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁省中药炮制工程技术研究中心,辽宁大连116600

出　　处：《中国药房》2014年第3期208-210,共3页China Pharmacy

基　　金：中医药行业科研专项项目(No.20110700713)

摘　　要：目的:研究四君子汤中生晒参与红参互换前后对脾气虚证模型大鼠的影响,比较其炮制作用,为四君子汤选择适宜的人参炮制品。方法:采用灌胃大黄(2 g/ml)和控制食量,每天1次,连续14 d,以复制大鼠脾气虚证模型。40只Wistar大鼠随机分为正常对照(等容生理盐水)组、模型(等容生理盐水)组、生晒参四君子汤(0.2 g/kg)组(简称生方组)与红参四君子汤(0.2 g/kg)组(简称红方组),复制模型结束后灌胃给药,每天1次,连续7 d。测定大鼠体质量、进食量,血清中血管活性肠肽(VIP)、一氧化氮(NO)、P物质(SP)、生长抑素(SS)、胃泌素(GAS)含量和胆碱酯酶(CHE)活性。结果:与正常对照组比较,模型组大鼠体质量、进食量减少,血清中GAS、SP含量减少,CHE活性减弱,SS、VIP、NO含量增加,差异具有统计学意义(P<0.05)。与模型组比较,生方组大鼠体质量、进食量增加,GAS、SP含量增加,CHE活性增强,SS、VIP、NO含量减少,差异具有统计学意义(P<0.05);红方组大鼠进食量增加,GAS、SP含量增加,CHE活性增强,SS、VIP、NO含量减少,差异具有统计学意义(P<0.05)。生方组以上指标均好于红方组。结论:生晒参之四君子汤与红参之四君子汤对脾气虚证模型大鼠均有较好的保护作用。就四君子汤治疗大鼠脾气虚证而言,用生晒参为宜。OBJECTIVE： To study the effects of sun-dried Ginseng and Red Ginseng in Sijunzi decoction on spleen-qi deficiency model rats, and to compare the processing effects and select processed products for Sijunzi decoction. METHODS： The spleen-qi deficiency model was induced by intragastrical administration of Rhei Radix Et Rhizoma（2 g/ml） and appetite control once a day for consecutive 14 days. 40 Wistar rats were randomly divided into normal control group （constant volume of normal saline）, model group （constant volume of normal saline）, Sijunzi decoction of sun-dried Ginseng group （0.2 g/kg） and Sijunzi de- coction of Red Ginseng group（0.2 g/kg）. They were given relevant medicines intragastrically once a day for consecutive 7 day after modeling. Body weight, food-intake, the contents of VIP, NO, SP, SS and GAS, CHE activity in serum were measured. RESULTS ： Compared with normal control group, body weight and food-intake were decreased, the contents of GAS and SP, the activity of CHE were decreased significantly in model group（P〈0.05）, while the contents of SS, VIP and NO were increased significantly（P〈0.05）. Compared with model group, body weight and food-intake were increased,the contents of GAS and SP, CHE activity were increased significantly, while the contents of SS, NO and VIP in sun-dried Ginseng group decreased significantly（P〈 0.05）. Food-intake was increased, the contents of GAS and SP, CHE activity were increased significantly, while the contents of SS, NO and VIP in red Ginseng group decreased significantly（P〈0.05） . All above index of sun-dried Ginseng group were better than those of Red Ginseng group. CONCLUSIONS： Sijunzi decoction of sun-dried Ginseng and Sijunzi decoction of Red Ginseng have good therapeutic effect on spleen-qi deficiency model rats; Sijunzi decoction of sun-dried Ginseng is suitable for the treatment of spleen-qi deficiency model.

关 键 词：红参 生晒参 四君子汤 脾气虚证 

分 类 号：R285[医药卫生—中药学] R245[医药卫生—中医学]