民族药紫金莲镇痛抗炎作用及急性毒性实验研究  

Study on the Ethnic Medicine Ceratostigma willmottianum Stapf for Its Analgesic and Anti-inflammatory Effects and Acute Toxicity Test

作　　者：卢启振 邓炜[1] 田宏平 李思科[1] 

机构地区：[1]贵阳中医学院药理教研室,贵阳550002

出　　处：《贵州科学》2014年第1期26-28,39,共4页Guizhou Science

基　　金：贵州省科学技术基金项目[黔科合中药字(2011)LKZ7033号]

摘　　要：对民族药紫金莲不同提取物镇痛抗炎作用及急性毒性进行实验研究。方法:以紫金莲醇提物、水提物采用醋酸扭体法、热板法,观察其对小鼠的镇痛作用;用二甲苯致鼠耳肿胀法观察其对小鼠抗炎作用;对2种提取物进行了最大耐受量测定。结果:紫金莲能明显减少醋酸致小鼠扭体次数,提高小鼠对热的痛阈值;小剂量抗炎作用明显;最大耐受量是人用剂量的250倍之多。结论:紫金莲两种提取物对小鼠镇痛抗炎作用显著,临床所用治疗剂量安全无毒。Study on the ethnic medicine Ceratostigma willmottianum Stapf （CWS） for its analgesic and antiin- flammatory effects and acute toxicity test. Methods：Hot-plate procedure and writhing test in mice were adopted in experiments of analgesic model with CWS extract of alcohol and water, and of anti-inflammatory model with mouse ear edema induced by xylene. The maximum tolerance for the two kinds of extracts was measured. Results：CWS could significantly reduce the writhing frequency caused by acetic acid, prolong the pain threshold on hot-plate in mice, and increase the anti-inflammatory effect with small dose. The maximum tolerance dose is 250 times more than the dose for human beings. Conclusions：The two CWS extracts have obvious analgesic and anti-inflammatory effects in mice and the clinical therapeutic dose is safe and non-toxic.

关 键 词：紫金莲 民族药 镇痛 抗炎 急性毒性 

分 类 号：R932.11[医药卫生—生药学]