丹红注射液对冠心病患者血液流变学影响的临床观察  

Study on effect of Danhong injection on blood rheological indices in patients with coronary artery disease(CAD)

作　　者：宋晓蓉[1] 谢陈玲[2] 

机构地区：[1]绵阳市人民医院急救部,四川绵阳621000 [2]成都市第六人民医院心内科,四川成都610000

出　　处：《临床和实验医学杂志》2014年第2期126-128,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的观察丹红注射液对冠心病患者的疗效及对血液流变学的影响。方法 80例冠心病患者,按照诊断标准确诊,随机分为治疗组和对照组,对照组给予稳定心肌细胞膜、扩冠及营养心肌等药物常规治疗,治疗组在常规治疗基础上加用丹红注射液30 ml加入5%葡萄糖溶液150 ml中静脉滴注,1次/d,14 d为1个疗程。观察两组治疗前后血液流变学指标全血黏度、血浆黏度、红细胞聚集指数、红细胞沉降率的变化,并与健康体检者(健康对照组)相对照。结果治疗组总有效率为92.5%,对照组总有效率为75.0%,治疗组总有效率明显高于对照组(P<0.05),治疗前治疗组和对照组各项指标均高于健康对照组(P<0.05),治疗后治疗组各项指标与健康对照组无显著差异(P>0.05)。治疗后第14天,治疗组红细胞沉降率、全血高、低切黏度、血细胞比容、全血低、高切还原黏度,血浆黏度值,红细胞聚集指数与治疗前比较显著下降(P<0.05),对照组治疗前后各项指标下降不明显(P<0.05)。结论丹红注射液能明显改善冠心病患者的各项血液流变学特性,无明显不良反应。Objective To observe the effect of Danhong injection on blood theological indices in patients with coronary artery disease. Methods A total of 80 patients with coronary heart disease were randomly divided into trial group and control group. Patients in control group were treated with routine therapy for myocardial cell membrane stability, dilatation of coronary artery and myocardial nutrition ; and patients in trial group were treated with routine therapy combined with Danhong injection, 30 ml in 5 % glucose solution 150 ml for intravenous infusion, and 14 d as a course. The changes in hemorheological indexes before and after treatment in patients of these 2 groups were observed. Results The total ef- fective rate of trial group was 92.5%, and it in control group was 75.0%, the total effective rate in trial group was obviously higher than that of control group （ P 〈 0.05 ）, the indicators in trim group before treatment were higher than those of healthy controls （ P 〈 O. 05 ）, the difference in indicators between trial group and control group after treatment was not significant （ P 〉 O. 05 ）. Fourteen days after treatment, the whole blood count, erythrocyte sedimentation rate, low shear viscosity, hematocrit, whole blood low cut and high reductive viscosity, plasma viscosity and e- rythrocyte aggregation index in trial group were significantly decreased compared with those before treatment （ P 〈 0.05 ）, the indicators in control group were not significantly decreased after treatment （ P 〈 0.05 ）. The changes in indicators of control group before and after treatment were not obvious, and the difference was also not statistically significant （ P 〉 0.05 ）. Conclusion The application of Danhong injection can significantly improve the blood rheological indices in patients with coronary heart disease.

关 键 词：冠心病 丹红注射液 血液流变学 临床疗效 

分 类 号：R259[医药卫生—中西医结合]